Advanced Topics in Forensic DNA Typing: MethodologyIntended as a companion to the Fundamentals of Forensic DNA Typing volume published in 2009, Advanced Topics in Forensic DNA Typing: Methodology contains 18 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field and citation to more than 2800 articles and internet resources. The book builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. This book provides the most detailed information written to-date on DNA databases, low-level DNA, validation, and numerous other topics including a new chapter on legal aspects of DNA testing to prepare scientists for expert witness testimony. Over half of the content is new compared to previous editions. A forthcoming companion volume will cover interpretation issues.
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Contents
| 1 | |
| 29 | |
| 49 | |
| 69 | |
5 Short Tandem Repeat STR Loci and Kits | 99 |
Principles and Instrumentation | 141 |
7 Quality Assurance and Validation | 167 |
Uses and Issues | 213 |
13 YChromosome DNA Testing | 371 |
14 Mitochondrial DNA Analysis | 405 |
15 XChromosome Analysis | 457 |
16 Nonhuman DNA | 473 |
17 New Technologies and Automation | 497 |
18 Legal Aspects of DNA Testing and the Scientific Expert in Court | 515 |
Appendix 1 Reported Sizes and Sequences of STR Alleles | 549 |
Potential Pitfalls and Privacy Concerns | 603 |
9 Missing Persons and Disaster Victim Identification Efforts | 271 |
10 Degraded DNA | 293 |
Issues Concerns and Solutions | 311 |
12 Single Nucleotide Polymorphisms and Applications | 347 |
Appendix 3 List of Suppliers for DNA Instruments Reagents Services | 611 |
Appendix 4 Interviews Supporting Legal Aspects of DNA Testing | 619 |
| 659 | |
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Common terms and phrases
allelic ladders amelogenin AmpFlSTR amplicons Applied Biosystems assay attorney autosomal Available biological bp Not published Budowle Butler capillary electrophoresis cells Chapter chromosome CODIS contains crime scene degraded DNA detection DNA analysis DNA evidence DNA extraction DNA profiles DNA quantitation DNA samples DNA sequencing DNA testing expert witness fluorescent forensic casework forensic DNA typing Forensic Genetics Forensic Science International forensic scientists gene Genetic Genealogy genome genotyping haplotype heteroplasmy Human Genetics human identification Identifiler individuals International Journal interpretation Journal of Forensic Journal of Legal Legal Medicine locus match method mitochondrial DNA mixture Molecular mtDNA multiplex mutation NIST nucleotide offender PCR amplification PCR primers PCR product performed polymerase polymerase chain reaction polymorphism population PowerPlex 16 Promega published STRBase reaction reference samples short tandem repeat standard STR alleles STR kits STR loci STR markers STR typing SWGDAM tion victim Y-chromosome Y-STR