Biological Basis of Oncologic Thermotherapy

adriamycin ascites Berg-Blok Beuningen bleomycin Cancer Res cancer therapy carcinoma carcinosarcoma cell line cell survival cells in vitro cellular changes CHO cells crease cyclophosphamide cytoskeleton cytotoxicity damage decrease Denekamp Dewey WC drug effect of hyperthermia exposure fibrosarcoma fractionated gene Gerweck glucose glycolysis Hahn GM heat shock heat shock proteins heat treatment hyper hyperglycemia hyperther hyperthermia Hyperthermic oncology hyperthermic treatment hypoxia hypoxic increase incubation induced inhibition Int J Hyperthermia Int J Radiat intracellular intratumor ionizing radiation irradiation Jain lactate malignant mammalian cells mammary melanoma melanoma cells membrane ment metabolic mice misonidazole mors motolerance mouse murine normal tissues observed Overgaard oxygen perfusion proteins Radiat Res radiosensitization RBC flux reduced skin Streffer studies survival curve synthesis ther thermal doses thermal enhancement thermia thermosensitivity thermotolerance tion tissue temperature tumor tumor blood flow tumor cells tumor tissue vascular Vaupel vitro vivo X-rays xenografts