Functional Metabolism: Regulation and AdaptationKenneth B. Storey Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields. |
Contents
| 1 | |
REGULATION AND ADAPTATION Chapter 2 Enzymes The Basis of Catalysis | 25 |
REGULATION AND ADAPTATION Chapter 3 Enzymes in the Cell Whats Really Going On? | 55 |
REGULATION AND ADAPTATION Chapter 4 Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli | 87 |
REGULATION AND ADAPTATION Chapter 5 Tyrosine Phosphorylation and the Control of Cellular Information | 125 |
REGULATION AND ADAPTATION Chapter 6 Control of Transcription in Eukaryotic Cells | 153 |
REGULATION AND ADAPTATION Chapter 7 Translational Controls and Protein Synthesis in Eukaryotic Cells | 189 |
REGULATION AND ADAPTATION Chapter 8 The Mitochondria Powerhouse of the Cell | 211 |
REGULATION AND ADAPTATION Chapter 11 Skeletal Muscle Metabolism and Plasticity | 295 |
REGULATION AND ADAPTATION Chapter 12 Oxygen in Biology and Biochemistry Role of Free Radicals | 319 |
REGULATION AND ADAPTATION Chapter 13 Oxidative Stress and Medical Sciences | 369 |
REGULATION AND ADAPTATION Chapter 14 Biochemical Adaptation | 383 |
REGULATION AND ADAPTATION Chapter 15 Oxygen Limitation and Metabolic Rate Depression | 415 |
REGULATION AND ADAPTATION Chapter 16 Mammalian Hibernation Biochemical Adaptation and Gene Expression | 443 |
REGULATION AND ADAPTATION Chapter 17 Cold Hardiness and Freeze Tolerance | 473 |
REGULATION AND ADAPTATION Chapter 18 Aspects of Blood Cell Biochemistry Erythrocytes Platelets and Stem Cells | 505 |
REGULATION AND ADAPTATION Chapter 9 Human Energy Metabolism in Health and Disease | 243 |
REGULATION AND ADAPTATION Chapter 10 Hormones in Human Metabolism and Disease | 271 |
REGULATION AND ADAPTATION Chapter 19 Organ Preservation for Transplantation | 529 |
REGULATION AND ADAPTATION Chapter 20 Metabolic Evolution and the Origin of Life | 557 |
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Common terms and phrases
action activity addition allows amino acids animals anoxia associated binding blood body Ca2+ catalytic causes cells cellular changes Chapter complex concentration contain cycle cytoplasm damage decrease domain effects energy enzyme equation example expression factors fatty acid Figure flux formation freezing function gene glucose glycogen glycolysis glycolytic growth hibernation hormone human important increase inhibition initiation insulin insulin receptor interactions involved kinetic known leads levels lipid liver major mechanisms mediated membrane metabolic mitochondrial molecules mRNA multiple muscle myosin occurs organs oxidative oxygen pathway phosphatase phosphorylation plasma platelet present production protein kinase pyruvate radical reaction receptor reduced regulation regulatory relative release response reversible role sequence shown shows signal skeletal muscle specific stimulation stress structure studies substrate subunit synthesis temperature Text Box tion tissue transcription transcription factors translation transport values whereas