Neurodegenerative Diseases: Neurobiology, Pathogenesis and TherapeuticsNeurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists. |
Contents
Part II Neuroimaging in neurodegeneration | 251 |
Part III Therapeutic approaches in neurodegeneration | 327 |
Part IV Normal aging | 381 |
Part V Alzheimers disease | 407 |
Part VI Other dementias | 471 |
Part VII Parkinsons and related movement disorders | 549 |
Other editions - View all
Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics M. Flint Beal,Anthony E. Lang,Albert C. Ludolph No preview available - 2005 |
Common terms and phrases
abnormal acid activity adult Alzheimer’s disease animals appears associated atrophy binding Biol bodies brain calcium cause cell death cells changes clinical cognitive complex cortex cortical damage decrease degeneration dementia demonstrated disorders dopamine dopaminergic early effects enzyme et al etal evidence expression factor familial findings formation function gene genetic glucose glutamate human imaging impairment important increased induced inhibition inhibitors involved lateral lead lesions levels loss mechanisms mice mitochondrial motor neurons mouse movement mutations Nature neuritic neurodegenerative Neurology Neurosci normal observed occur ofthe oxidative Parkinson’s disease pathology pathway patients Pick’s disease potential present prion Proc production progressive protein radical recent receptor reduced regions reported response role selective signal specific striatal structural studies suggest superoxide tion toxicity transgenic transport treatment trials vectors vivo