Neurodegenerative Diseases: Neurobiology, Pathogenesis and TherapeuticsNeurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists. |
Contents
Part II Neuroimaging in neurodegeneration | 251 |
Part III Therapeutic approaches in neurodegeneration | 327 |
Part IV Normal aging | 381 |
Part V Alzheimers disease | 407 |
Part VI Other dementias | 471 |
Part VII Parkinsons and related movement disorders | 549 |
Other editions - View all
Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics M. Flint Beal,Anthony E. Lang,Albert C. Ludolph No preview available - 2005 |
Common terms and phrases
abnormal acid activity Alzheimer Alzheimer's disease amyloid amyotrophic lateral sclerosis apoptosis Aẞ associated atrophy axonal BDNF binding Biochem Biol Brain Res calcium caspase cell death cellular cerebral Chem clinical cognitive cortex cortical Creutzfeldt-Jakob disease decrease degeneration diagnosis disorders dopamine dopaminergic neurons dystonia effects enzyme excitotoxic expression factor frontal frontotemporal dementia function gene genetic glial glutamate transporter hippocampal human Huntington's disease imaging impairment increased induced inhibition inhibitors isoforms lesions levels Lewy bodies mechanisms metabolism mitochondrial molecular monkeys motor neuron MPTP mutations Natl Acad Neurochem neurodegenerative diseases Neurology neuropathology Neurosci neurotoxicity NMDA normal oxidative Parkinson's disease pathology pathway patients peptide peroxynitrite phenotype plaques potential prion Proc proteasome protein receptor regions resonance role scrapie signal SOD1 specific spinal striatal striatum studies substantia nigra superoxide dismutase syndrome tau protein tion tissue toxicity transgenic transgenic mice treatment vectors vitro vivo