Crucible of Science: The Story of the Cori Laboratory

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Oxford University Press, May 23, 2013 - Science - 226 pages
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"Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful in attracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, "Crucible of Science" is a unique presentation of remarkable careers and personalities, examined within the context of the Coris' laboratory.
  

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Contents

Early Life
1
Their First Graduate Student
16
The Great Dane
21
Spanish Genius
29
5 Move to Enzymology and Work of Arda Green
39
One of Argentinas Greatest Scientists
45
Master of Intuition
53
Award of Nobel Prizes and Career of Tom Cori
67
Enthusiast for Science
139
18 Gerty Coris Work on Glycogen Structure and Glycogen Storage Diseases
145
Focus on Glycogen Synthase
149
20 Contributions of Barbara and David Brown
161
All About Growth
165
A Decade with Carl Cori
171
Spanish Enzymologist
176
The Complexity of Carbohydrates
181

Modest Enzymologist
73
Pediatrician and Immunochemist
78
Accidental Biochemist
82
Against All Odds
91
Belgian with Savoir Faire
100
A Giant of Biochemistry
112
15 Hormone Effects on Muscle Carbohydrate Metabolism
123
Aristocratic Physiologist
127
Jovial Bavarian
189
Enzyme Kineticist
196
Focus on Diabetes
201
Academic Leader
206
29 The Influence of the Coris on Washington University and Carl Coris Research at Boston
210
30 The Heritage of the Coris
214
Index
221
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About the author (2013)


John H. Exton is Professor of Molecular Physiology and Biophysics at the Vanderbilt University School of Medicine, and Investigator at Howard Hughes Medical Institute.

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