Parasitic Helminths: Targets, Screens, Drugs and VaccinesConor R. Caffrey This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists. |
Contents
Integrating and Mining Helminth Genomes | |
Recent Progress in Transcriptomics of | |
Harnessing Genomic Technologies to Explore | |
RNA Interference A Potential Discovery Tool | |
RNA Interference as a Tool for Drug Discovery | |
Promise of Bacillus thuringiensis Crystal | |
Monepantel From Discovery to Mode of Action | |
Discovery Mode of Action | |
Acetylcholine Receptor Antagonist | |
Praziquantel Too Good to be Replaced? | |
Drug Discovery for Trematodiases Challenges | |
Barefoot thru the Valley of Darkness | |
Vaccines Linked to Chemotherapy A | |
Screens | |
Established LGIC Anthelmintic Drug Targets | |
Identification | |
Quantitative HighContent ScreeningBased | |
Use of Rodent Models in the Discovery of Novel | |
To Kill a Mocking Worm Strategies to Improve | |
Drugs | |
Anthelmintic Drugs Tools and Shortcuts for | |
Antinematodal Drugs Modes of Action | |
Drugs and Targets to Perturb the Symbiosis | |
Antifilarial Vaccine Development Present | |
Proteases as Vaccines Against Gastrointestinal | |
Schistosomiasis Vaccines New Approaches | |
Sm14 Schistosoma mansoni Fatty AcidBinding | |
Mechanisms of Immune Modulation by Fasciola | |
Prospects for Immunoprophylaxis Against | |
Vaccines Against Cestode Parasites | |
Other editions - View all
Parasitic Helminths: Targets, Screens, Drugs and Vaccines Conor R. Caffrey No preview available - 2012 |
Common terms and phrases
acetylcholine receptor Acids activity adult agonists albendazole analysis animals annotation anthelmintic anthelmintic drug antiparasitic Ascaris assay benzimidazoles Biochem bioinformatic Biol biological Brugia malayi Caenorhabditis elegans cathepsin cells Chem chemical chloride channel clinical colubriformis compounds Cry proteins Cry5B Curr database datasets diseases dose double-stranded RNA doxycycline drug development drug discovery drug targets effects efficacy eggs emodepside encoding enzyme essential Fasciola hepatica Figure filarial filariasis flatworms free-living functional Geary gene expression genetic genome genome sequence Haemonchus contortus helminth helminth infections high-throughput hookworm host Hotez human identified inhibitors intestinal ivermectin larvae levamisole liver flukes mebendazole mice molecular molecules monepantel mutants nAChR nicotinic novel orthologs parasitic nematodes Parasitology pathway phenotype PLoS potential praziquantel predicted proteases protein reduced transcript RNA interference RNAi roundworms Schistosoma mansoni schistosomiasis screening sensitivity siRNA species strategy studies subunits transcriptomic treatment Trends Parasitol Trichostrongylus vaccine veterinary vitro viverrini vivo Wolbachia worms