Parasitic Helminths: Targets, Screens, Drugs and Vaccines

Front Cover
Conor R. Caffrey
John Wiley & Sons, May 24, 2012 - Medical - 540 pages
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development.
With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.
 

Contents

Preface
Targets
How Relevant is Caenorhabditis elegans as a Model
Integrating and Mining Helminth Genomes
Recent Progress in Transcriptomics of
Harnessing Genomic Technologies to Explore
RNA Interference A Potential Discovery Tool
RNA Interference as a Tool for Drug Discovery
Promise of Bacillus thuringiensis Crystal
Monepantel From Discovery to Mode of Action
Discovery Mode of Action
Acetylcholine Receptor Antagonist
Praziquantel Too Good to be Replaced?
Drug Discovery for Trematodiases Challenges
Barefoot thru the Valley of Darkness
Vaccines Linked to Chemotherapy A

Screens
Established LGIC Anthelmintic Drug Targets
Identification
Quantitative HighContent ScreeningBased
Use of Rodent Models in the Discovery of Novel
To Kill a Mocking Worm Strategies to Improve
Drugs
Anthelmintic Drugs Tools and Shortcuts for
Antinematodal Drugs Modes of Action
Drugs and Targets to Perturb the Symbiosis
Antifilarial Vaccine Development Present
Proteases as Vaccines Against Gastrointestinal
Schistosomiasis Vaccines New Approaches
Sm14 Schistosoma mansoni Fatty AcidBinding
Mechanisms of Immune Modulation by Fasciola
Prospects for Immunoprophylaxis Against
Vaccines Against Cestode Parasites
Index
Copyright

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About the author (2012)

Volume editor:
Conor R. Caffrey completed his Ph.D. thesis research in 1993 at University College Dublin. He then moved to the Department of Tropical Medicine and Hygiene at the University of Heidelberg as a Wellcome Trust Travelling Research Scholar. Between 1998 and 2000, he was a post-doctoral scholar at the Department of Pathology of the University of California San Francisco. After a brief faculty appointment at the University of Wales, Aberystwyth, Dr. Caffrey returned to UCSF in 2001 to direct the Biochemistry and Molecular Parasitology Core of the Sandler Center the Sandler Center for Basic Research in Parasitic Diseases (now the Sandler Center for Drug Discovery). Dr. Caffrey?s current research focus is pre-clinical drug discovery for tropical infectious diseases, particularly schistosomiasis and African trypanosomiasis.

Series Editor:
Prof. Dr. Paul M. Selzer studied Biology, Parasitology, and Biochemistry at the University of Tubingen, Germany, where he also received his PhD in Biochemistry on subjects related to the protozoan parasite Trypanosoma brucei. As a post-doctoral fellow he spent three years in the parasitology and tropical disease laboratory of Prof. James H. McKerrow at the University of California, San Francisco (UCSF). Within the Molecular Design Institute at UCSF Dr. Selzer was introduced to modern drug discovery approaches and technologies. He broadened his scientific and business knowledge as a researcher within diverse pharmaceutical companies including Boehringer Mannheim GmbH, Germany, SmithKline Beecham p.l.c., UK, Hoechst Roussel Vet GmbH, Germany, and finally Intervet Innovation GmbH, Germany, a part of Intervet/Schering-Plough Animal Health. Dr. Selzer is also a teacher in Biochemistry, Bioinformatics, and Chemoinformatics at the University of Tubingen in the Department of Biochemistry, which awarded him the title of Professor for his achievements in teaching and research. In 2008, he was also awarded an Honorary Professorship in the Department of Infection and Immunity at the University of Glasgow, UK.

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