The Hormonal Control of Gene TranscriptionP. Cohen, J.G. Foulkes Over the past few years there have been considerable advances in our understanding of cellular control mechanisms, and current research is now linking areas of biology that were previously thought of as being quite separate. Molecular Aspects of Cellular Regulation is a series of occasional books on multidisciplinary topics which illustrate general principles of cellular regulation. Previous volumes described Recently Discovered Systems of Enzyme Regulation by Reversible Phosphorylation (Volumes 1 and 3), The Molecular Actions of Toxins and Viruses (Volume 2), Molecular Mechanisms of Transmembrane Signalling (Volume 4) and Calmodulin (Volume 5). This sixth volume, The Hormonal Control of Gene Transcription, has now been published to highlight recent important advances in our understanding of this topic which is linking two of the most active areas of current biochemical and molecular biological research (hormone action and gene transcription) and leading to the emergence of unifying concepts. |
Contents
Regulation by hormone receptorDNAbinding proteins the steroid superfamily | 99 |
Regulation of transcription by second messenger systems | 159 |
Regulation of transcription by polypeptide hormones | 255 |
Regulation of transcription by environmental stress | 375 |
Transcriptional regulation and development | 447 |
| 489 | |
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Acad amino acid AP-l assays basal binding Biochem Biol c-fos c-jun cAMP cDNA Cell 55 cell line cell types cellular Chem chromatin cloned complex contain CREB cycloheximide defined differentiation dimerization DNA-binding domain Drosophila dsRNA EMBO encoding enzyme eukaryotic fibroblasts first function gene expression gene transcription Genes Dev glucocorticoid growth factors heat shock homeobox identified IFN-inducible IFN-y immediate early genes induced influence inhibition initiation insulin interactions levels mechanisms mediated modification motif mRNA mutation Natl Nature NF-KB nuclear octamer phosphorylation PK-A Proc promoter protein kinase protein synthesis purified region regulation regulatory response element retinoic acid receptor RNA polymerase RNA polymerase II role Science sequence significant specific steroid stimulation structure studies subunit suggest T3 receptor TATA box TFIID thyroid hormone tion trans-acting factors transcription factors transcriptional activation transfected unpubl uPA gene uPA mRNA upstream vitro