Primary Immunodeficiency Disorders: A Historic and Scientific PerspectiveAmos Etzioni, Hans D. Ochs Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way.
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Contents
| 1 | |
| 13 | |
| 29 | |
Chapter 4 From Immunodeficiency to Autoimmunity | 41 |
Chapter 5 Immunological Tests from the Microscope to Whole Genome Analysis | 51 |
Chapter 6 Primary Immunodeficiency in the Developing Countries | 65 |
Chapter 7 Jeffrey Asked Us to Do Something Our Journey | 77 |
Dates of description and gene discovery of major PIDDs | 82 |
Chapter 15 Severe Combined Immunodeficiency as Diseases of Defective Cytokine Signaling | 181 |
Chapter 16 The Hyper IgM Syndromes a Long List of Genes and Years of Discovery | 197 |
Chapter 17 Unraveling the Complement System and its Mechanism of Action | 217 |
A Serendipitous Discovery | 229 |
Chapter 19 The Many Faces of the HyperIgE Syndrome | 241 |
Chapter 20 ADA Deficiency The First Described Genetic Defect Causing PID | 255 |
Chapter 21 The Leukocyte Adhesion Deficiency Story | 267 |
Chapter 22 How Common Variable Immune Deficiency has Changed Over Six Decades | 275 |
The AtaxiaTelangiectasia Gene and its Function | 83 |
from a Fatal Hematologic Disorder to a Curable Immunodeficiency | 97 |
Chapter 10 Neutropenia More Genetic Defects Than Ever Expected | 111 |
from Xlinked Recessive to Autosomal Recessive Agammaglobulinemia | 127 |
Chapter 12 The Discovery of the Familial Hemophagocytosis Syndromes | 139 |
Chapter 13 Chronic Granulomatous Disease from a Fatal Disease to a Curable One | 151 |
Chapter 14 Severe Combined Immunodeficiency from Discovery to Newborn Screening | 171 |
Other editions - View all
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective Amos Etzioni,Hans D. Ochs No preview available - 2018 |
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective Amos Etzioni,Hans D. Ochs No preview available - 2014 |