The Autoimmune DiseasesM. Eric Gershwin, George C. Tsokos Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. New to This Edition:* Tissue-specific interventions to arrest or "cure" autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter |
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activation alleles animal models anti antibodies antigen antigen-specific antiphospholipid antiphospholipid syndrome APCs apoptosis apoptotic Arthritis Rheum associated autoantibodies autoantigens autoimmune disease autoreactive T cells binding CD4+ T cells CD4+CD25+ Tregs CD8+ cell receptor chemokine Clin clinical costimulatory cytokines cytotoxic dendritic cells effector effects epitopes expression factor function gene genetic human IFN-g immune complexes immune response immune system immunoglobulin Immunol immunologic induced infection inflammatory inhibit interactions interleukin ligand lymphocytes lymphoid macrophages mechanisms mediated memory B cells MHC class molecular mouse multiple sclerosis murine naïve negative selection NOD mice pathogenesis pathogenic pathway patients peptide peripheral polymorphism production protein reactive regulation regulatory T cells repertoire rheumatoid arthritis Rheumatol role self-antigen self-reactive signaling Sjögren’s syndrome specific studies suppression susceptibility systemic lupus erythematosus T-cell target thymic thymus tion tissue tolerance transgenic transgenic mice type 1 diabetes vaccination vitro vivo