Reflections on a Century of Malaria Biochemistry: Reflections on a Century of Malaria Biochemistry

Front Cover
Academic Press, Aug 29, 2011 - Medical - 400 pages
0 Reviews
Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.

This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.

* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria

* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research
  

What people are saying - Write a review

We haven't found any reviews in the usual places.

Related books

Contents

Introduction
1
An Introduction to Malaria Parasites
3
The Early Years
9
Show Me the Money
15
In Vivo and In Vitro Models
25
Malaria Pigment
49
Chloroquine and Hemozoin
59
Isoenzymes
63
Polyamines
147
New Permeability Pathways and Transport
151
Hemoglobinases
171
Erythrocyte Surface Membrane Proteins
181
Trafficking
205
Erythrocyte Membrane Lipids
215
Invasion of Erythrocytes
229
Vitamins and AntiOxidant Defenses
253

The Road to the Plasmodium falciparum Genome
73
Carbohydrate Metabolism
87
Pyrimidines and the Mitochondrion
95
The Road to Atovaquone
101
The Ring Road to the Apicoplast
105
Ribosomes and Ribosomal Ribonucleic Acid Synthesis
111
De Novo Synthesis of Pyrimidines and Folates
117
Salvage of Purines
139
Shocks and Clocks
271
Transcriptomes Proteomes and Data Mining
279
Mosquito Interactions
299
References
325
Index
395
Contents of Volumes in this Series
403
Copyright

Other editions - View all

Common terms and phrases