Reflections on a Century of Malaria BiochemistryMalaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa. This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.
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Contents
| 1 | |
| 3 | |
| 9 | |
| 15 | |
| 25 | |
Malaria Pigment | 49 |
Chloroquine and Hemozoin | 59 |
Isoenzymes | 63 |
Polyamines | 147 |
New Permeability Pathways and Transport | 151 |
Hemoglobinases | 171 |
Erythrocyte Surface Membrane Proteins | 181 |
Trafficking | 205 |
Erythrocyte Membrane Lipids | 215 |
Invasion of Erythrocytes | 229 |
Vitamins and AntiOxidant Defenses | 253 |
The Road to the Plasmodium falciparum Genome | 73 |
Carbohydrate Metabolism | 87 |
Pyrimidines and the Mitochondrion | 95 |
The Road to Atovaquone | 101 |
The Ring Road to the Apicoplast | 105 |
Ribosomes and Ribosomal Ribonucleic Acid Synthesis | 111 |
De Novo Synthesis of Pyrimidines and Folates | 117 |
Salvage of Purines | 139 |
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Common terms and phrases
activity adhesion amino acid anti-malarial antibodies antigen apicoplast asexual binding Biochem biochemistry Biol biology biosynthesis Carter cerebral malaria chabaudi characterization Chem chloroquine chromosome cloned Cowman culture cycle dehydrogenase domain drug Duffy encoding enzyme erythrocytes exflagellation expression falciparum genome falciparum-infected red cells folate function gallinaceum gametocytes gene genetic genome glycophorin hemoglobin hemozoin hepatocytes host cell human malaria immune infected red cells inhibited inhibitors invasion involved isolated laboratory lipid lophurae malaria parasite Plasmodium malaria research malaria-infected Maurer’s clefts membrane merozoite metabolism Microbiol Miller mitochondrial mitochondrion molecular monkeys mosquito nucleoside oocyst ookinete oxidative Parasitol Parasitology pathway PfEMP1 plasma plasmepsins plasmodial Plasmodium berghei Plasmodium falciparum Plasmodium knowlesi post-doctoral protease protein proteomic purine pyrimethamine pyrimidine receptor red blood cells red cells resistance rodent malaria role sequence Sherman specific sporozoites stages studies suggested surface synthesis target Trager transcription transport trophozoite United Kingdom University vaccine vitro vivax vivo Wellcome yoelii