An Atlas of Preimplantation Genetic DiagnosisThis color-illustrated atlas and clinical textbook by two respected authorities details the procedures for diagnosing genetic disease in gametes prior to fertilization and in embryos fertilized in vitro prior to uteral implantation. With over 200 full-color images, the book sets out the current methods used in oocyte and preembryo sampling along with the latest techniques in DNA and cytogenetic analysis in preimplantation development. Includes bibliographic references and index. Authors Verlinsky and Kuliev are well-known experts on this subject with two previous books to their credit. |
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abnormal AF508 mutation amplification aneuploidies Assist Reprod Genet biopsy blastocyst blastomere blastomere biopsy bodies and blastomeres centromeric chromatid Chromatid error chromosome 18 chromosomes tested corresponding oocyte cumulus cells cytoplasm derivative of chromosome derived reciprocal translocation detected dish error in meiosis exon fertilization FISH analysis five-color FISH genotype gold arrow green arrow heterozygous holding pipette homozygous hybridization ICSI injection intron IVF patient linked markers maternally derived meiosis metaphase chromosomes metaphase II metaphase II oocytes microneedle micropipette Midwest Scientific misdiagnosis mutant allele mutation nested PCR normal allele oocyte oocyte retrieved orange PBI and PB2 PBI PB2 PBI PCR product perivitelline space polar body analysis polar body PBI polar body removal pregnancy preimplantation genetic diagnosis preselection present primers red arrows restriction digestion resulting embryo second PB2 second polar body signal for chromosome single-gene disorders specific for chromosomes sperm thalassemia transfer trisomy Verlinsky white arrow zona pellucida zygote