Antidotes: Principles and Clinical Applications
Antidotes provides up-to-date information on the development and clinical use of antidotes, their proposed mechanism of action, toxicity, availability and practical aspects of their clinical use. The antidotes discussed are primarily those either in current use, or under consideration or development. Some other compounds of mainly historical interest are also mentioned where appropriate. It contains information on the antidotal treatment of poisoning with compounds encountered not only in Western Europe, North America and Australia, but also developing countries. It covers source, shelf-life and instances where antidote administration complicates or compromises laboratory analyses.
There is no other single, published work that looks generally at antidotes, and it will prove invaluable to researchers, staff in poison information centers and A&E wards, drug information pharmacists, medical toxicologists and veterinarians. It will also be useful reading for medical students, trainee pharmacists, emergency physicians, ambulance staff and anesthetists.
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absorption acid activated charcoal administration Ann Emerg antagonist antibody fragments antivenin Aposhian arsenic atropine benzodiazepine blood lead concentrations calcium disodium edetate carbon monoxide chelating agents chelation therapy cholinesterase Clin Pharmacol compounds cyanide antidotes cyanide poisoning D-glucose D-penicillamine dantrolene deferiprone deferoxamine diazepam dicobalt edetate digoxin dimercaprol DMPS DMSA Dose adult drug EDTA effective efficacy enzyme ethanol excretion exposure Fab fragments Figure flumazenil fomepizole given i.v. glucagon glycol hepatic Hum Exp Toxicol Hum Toxicol hydroxocobalamin i.v. infusion ingestion injection intoxication iron Lancet lead poisoning mercury Meredith metabolism metal ions methaemoglobin methaemoglobinaemia methylthioninium chloride mg/kg mg/L N-acetylcysteine naloxone nerve agents obidoxime opioid oral overdose oximes oxygen paracetamol poisoning paraquat pharmacokinetics phosgene Plasma half-life potassium pralidoxime Presentation/supply rats reactions renal respiratory reverse serum sodium bicarbonate sodium nitrite sodium thiosulphate Structural formula studies sulphate sulphur mustard toxicity Toxicol Clin Toxicol Toxicology treat poisoning Ug/L urine venom vitamin vomiting µg/L