Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries

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Royal Society of Chemistry, 2000 - Science - 313 pages
The continuing quest for new drugs and agrochemicals has seen researchers looking to the natural world for potential products. Plants and microorganisms have long been investigated as sources of new lead compounds, but the scope of this book has been widened to include substances derived from marine organisms. Advances in genetic engineering, high throughput screening and structure elucidation have also opened up further avenues for exploration. Competitive pressure from the field of combinatorial chemistry has expedited new approaches to natural product analysis and stimulated debate on the industrial utilization of natural products. Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries reviews and discusses aspects of modern natural products research. The central theme of many articles is the sustainable use of global biodiversity. Microbial, plant and marine products are presented as the sources of new drugs, including antifungal products, antibiotics, anticancer agents and animal health products. There is also coverage of the biosynthesis of polyketides and the chemical synthesis of natural products and their derivatives. A unique blend of industrial and academic perspectives on the importance of biodiversity and natural products, this book will prove an important source of state-of-the-art information for researchers, teachers and graduates in the chemical and biological sciences.
 

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Contents

A Past with a Future
3
New Concepts and Approaches to Biodiversity
17
Secondary Metabolites as a Vital Source of Animal Health Products
45
The Relationship Between Natural Products and Synthetic Chemistry
59
A Case Study
66
Mushrooms Microbes and Medicines
75
Signal Transduction Inhibitors from Microorganisms
86
Novel Inhibitors of Lipoprotein Associated Phospholipase A2 Produced
100
Water Soluble Bioactive Alkaloids
169
Can Ecology Provide New Leads in the Search
205
A Source of Phytomedicines Natural Drugs
213
A Moder n Perspective to the Traditional Use of Plants in the Highlands
225
Understanding and Exploiting
233
Fused Ring Aromatic Polyketides are Formed by Different Cyclisation
249
The Strobilurin Fungicides From Mushroom to Molecule to Market
277
A Synthesis of +PrelogDjerassi Lactonic Acid
283

Marine Organisms as a Source of Novel Lead Structures for Drug
113
The Anticancer Dolastatins as Cyanobacterial Metabolites
126
A Cu2+ Selective Marine Metabolite
140

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