Biological and Biomedical Infrared Spectroscopy

Front Cover
Andreas Barth, Parvez I. Haris
IOS Press, 2009 - Science - 429 pages
Although infrared spectroscopy has been applied with success to the study of important biological and biomedical processes for many years, key advances in this vibrant technique have led to its increasing use, ranging from characterization of individual macromolecules (DNA, RNA, lipids, proteins) to human tissues, cells and their components. Infrared spectroscopy thus has a significant role to play in the analysis of the vast number of genes and proteins being identified by the various genomic sequencing projects. Whilst this book gives an overview of the field, it highlights more recent developments, such as the use of bright synchrotron radiation for recording infrared spectra, the development of two-dimensional infrared spectroscopy and the ability to record infrared spectra at ultra fast speeds.
 

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Contents

Infrared Spectroscopy Past and Present
1
The Study of Protein Reactions by ReactionInduced Infrared Difference Spectroscopy
53
Ultrafast 2DIR Vibration Echo Spectroscopy of Proteins
79
FTIR Data Processing and Analysis Tools
104
FTIR Spectroscopy for Analysis of Protein Secondary Structure
129
Infrared Spectroscopy of Protein Pharmaceuticals
168
Quantum Mechanical Calculations of Peptide Vibrational Force Fields and Spectral Intensities
178
Computational Linear and Nonlinear IR Spectroscopy of Amide I Vibrations in Proteins
224
Application of IsotopeEdited FTIR Spectroscopy to the Study of ProteinProtein Interactions
261
Biomedical FTIR Spectroscopy of Lipids
272
Structural Analysis of ProteinDNA and ProteinRNA Interactions by FTIR Spectroscopy
288
FTIR Spectroscopy of Cells Tissues and Body Fluids
312
Biomedical Applications of Near Infrared Spectroscopy
355
The Use of Synchrotron Radiation for Biomedical Applications of Infrared Microscopy
403
Author Index
429
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