Biological Basis Of Oncologic Thermotherapy
Michel Gautherie, Christian Streffer, Peter Vaupel, George M. Hahn
Springer-Verlag Berlin And Heidelberg Gmbh & Company K, 1990 - Cancer - 169 pages
This volume deals with the biological and pathophysiological basis of thermotherapy in a comprehensive manner and thus provides basic information to researchers investigating the various phenomena involved in the interaction between heat and living cells or tissue, as well as to clinicians who are undertaking therapeutic trials of hyperthermia, especially in cancer treatment. Along with an updated review of the mechanisms of cell killing by heat, particular emphasis is laid upon ongoing research on topics which are of utmost importance with regard to the definition of treatment protocols and understanding of the tumor response to thermotherapy. These include effects of hyperthermia on blood flow rates and microcirculation in normal and malignant tissue, enhancement of radiation and drug-induced cell killing by hyperthermia, genetic and biochemical processes governing the heat schock response, and the phenomena of thermosensitivity and thermotolerance vs. thermoresistance.
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Biological Basis of Thermotherapy
Pathophysiological Mechanisms of Hyperthermia
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acid adriamycin ascites Beuningen bleomycin Cancer Res carcinoma cell killing cell line cell survival cells in vitro cellular changes Chinese hamster CHO cells combined crease cytoskeleton cytotoxicity damage decrease Denekamp Dewey WC Drosophila drug effects of hyperthermia exposure fibrosarcoma genes Gerweck glucose glycolysis Hahn GM heat shock proteins heat shock response heat treatment heat-induced hyper hyperglycemia hyperther hyperthermia Hyperthermic oncology hyperthermic treatment hypoxia hypoxic increase incubation induced inhibition Int J Hyperthermia Int J Radiat intratumor ionizing radiation irradiation Kallinowski lactate malignant mammalian cells mammary melanoma melanoma cells membrane ment metabolic mice misonidazole mors motolerance mouse Mueller-Klieser murine normal tissues observed Oncol Biol Phys Overgaard oxygen perfusion Radiat Oncol Biol Radiat Res radiosensitization RBC flux Streffer studies ther thermal doses thermal enhancement thermia thermosensitivity thermotolerance tion tissue temperature tumor blood flow tumor cells tumor tissue vascular Vaupel vitro vivo X-rays xenografts