Cytochrome P450: Structure, Mechanism, and Biochemistry, Page 450

Front Cover
Springer Science & Business Media, 2005 - Medical - 689 pages
0 Reviews

Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.

 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Conclusion
5
Acknowledgments
34
Computational Approaches to Cytochrome P450 Function
45
QM Studies of P450 Reactivity Pattems
66
References
80
Introduction
86
References
111
Acknowledgments
138
116
318
1
319
Induction of Cytochrome P450 Enzymes
323
52
328
56
336
117
340
59
342
Hormonal Regulation of Liver Cytochrome P450 Enzymes
347

Activation of Molecular Oxygen by Cytochrome P450
149
Enzymatic Cycle of Cytochrome P450
155
Structural Input into the Mechanisms of P450Catalyzed Dioxygen Activation
161
Substrate Oxidation by Cytochrome P450 Enzymes
183
Heteroatom Oxidation and Dealkylation
193
14
199
Oxidation of Aromatic Rings
202
Dehydrogenation Reactions
208
29
211
44
222
54
228
Conclusions
229
Ruthenium Porphyrins in Oxidative Catalysis
233
Inhibition of Cytochrome P450 Enzymes
247
CatalysisDependent Inhibition
250
P450 Enzyme Specificity
285
Summary
294
45
297
91
299
Acknowledgment
366
Human Cytochrome P450 Enzymes
377
General Issues of Variability and Polymorphism
383
Relevance of P450s in Toxicology and Cancer Risk
395
56
448
Acknowledgments
463
Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic
531
Conclusion
545
Cytochrome P450s in Plants
552
AType P450s Mediating Plant Protection
559
P450 Mediated Production of Alkaloids with Medicinal Importance
571
The Diversity and Importance of Microbial Cytochromes P450
585
Archetypal Bacterial CYPs
594
Azole Antifungals and the Evolution of New Resistant Genes
603
Conclusions
610
Human and Rat Liver Cytochromes P450 Functional
619
Index
659
Copyright

Other editions - View all

Common terms and phrases

Bibliographic information