Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools
Sean Ekins, Jinghai J. Xu
John Wiley & Sons, Jan 28, 2009 - Medical - 336 pages
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
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acid activity analysis analytes animal antibody applications approach aptamer assay binding bioavailability Biochem Bioinformatics Biol biological biomarkers cardiac cardiomyocytes CellCiphr cellular Chem chemical chitosan cholesterol clinical complex compounds computational correlation database differentiation disease dose dose–response drug delivery Drug Discov drug discovery effects efficacy Ekins embryonic stem cells enzymes evaluation experimental factors Figure functional gene expression genetic genomic glycans glycomics hepatic hepatocytes hepatotoxicity high-throughput human identify inhibitor interactions intestine levels lipid liposomes liver measurements mesenchymal stem cells metabolism methods mice microarrays module molecular molecules nanoparticles Nat Biotechnol nodes oral delivery pathways peptide Pharm pharmaceutical pharmacokinetic Pharmacol phenotype PLGA polymer polymeric nanoparticles potential preclinical prediction profiling protease protein proteomic receptor response RNAi safety screening sequence signaling siRNA specific studies systems biology target telemetry testing therapeutic therapy tion tissue toxicity Toxicol toxicology transcription vitro vivo zebrafish