Free radicals in biology and medicine
Now in a new edition, this volume meets the need for a complete, in-depth guide to the important new field of radical reactions. The text is extensively revised and fully updated. It provides biologists, clinicians and other nonchemists with an easy-to-understand study of the nature of free radicals, including explanations of what they are, how they are generated, and how they can react, both in normal body chemistry and as the mode of action for many dangerous toxins. The role of radical reactions in several key biological is critically evaluated. Useful appendices give the reader information on atomic structure and bonding, and a simple guide to lymphocytes.
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Oxygen is poisonousan introduction to oxygen toxicity and free
The chemistry of oxygen radicals and other oxygenderived species
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agents animals antioxidant aqueous ascorbic acid assay atom bacteria binding Biochem Biol biological Biophys bleomycin blood bonds cancer catalase cause cells Chapter chelating Chem chloroplasts coli complex compounds contain copper CuZnSOD cytochrome decrease dehydrogenase desferrioxamine disease drugs effects electrons enzyme erythrocytes fatty acids Fe(III Fe2+ FeSOD fluid formation free radicals free-radical glutathione peroxidase haem haemoglobin HOC1 human hydrogen peroxide hydroperoxide hydroxyl radicals inactivated increased inflammation inhibition injury intracellular iron ions lipid peroxidation lipoxygenase liver lung macrophages mechanism membrane lipids metabolism metal ions microsomal mitochondria MnSOD molecule NADH NADPH neutrophils normal organic oxidation oxygen concentrations oxygen radicals paraquat patients peroxy radicals phagocytic pigment plant plasma present produced protect protein radical reactions rats react reactive reduced reductase release rheumatoid role scavengers Section singlet oxygen SOD activity species stimulate structure substrate superoxide dismutase synthesis Table tissues toxicity tumour vitamin vitro vivo xanthine oxidase