Free Radicals in Biology and Medicine"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET. |
Contents
Oxygen is poisonousan introduction to oxygen toxicity and free | 1 |
The chemistry of oxygen radicals and other oxygenderived species | 22 |
the superoxide | 86 |
Copyright | |
7 other sections not shown
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Common terms and phrases
agents animals antioxidant ascorbic acid assay atom bacteria Biochem Biol biological Biophys bleomycin blood bonds cancer catalase cause cells Chapter chelating Chem chloroplasts coli complex compounds contain copper CuZnSOD cytochrome decrease dehydrogenase desferrioxamine disease DNA damage drugs effects electrons enzyme erythrocytes fatty acids Fe(III Fe² FeSOD fluid formation free radicals free-radical glutathione peroxidase H₂O H₂O₂ haem haemoglobin human hydrogen peroxide hydroperoxide hydroxyl radical inactivated increased inflammation inhibition injury intracellular iron ions lipid peroxidation liver lung macrophages mechanism membrane lipids metabolism metal ions microsomal MnSOD molecule NADH NADPH neutrophils normal O₂ oxidation oxygen concentrations oxygen radicals paraquat patients phagocytic pigment plant plasma present produced protect protein radical reactions rats react reactive reduced reductase release rheumatoid role scavengers Section singlet oxygen SOD activity species stimulate structure substrate superoxide dismutase synthesis tion tissues toxicity tumour vitamin vitamin E vitro vivo xanthine oxidase