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BASIC THEORY OF GROWING CELL POPULATIONS
EXPERIMENTAL TECHNIQUES FOR CELL KINETIC STUDIES
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3H-thymidine age distribution ascites ascites tumour assay autoradiographic carcinoma cell cycle cell kill cell kinetics cell loss factor cell number cell population kinetics cell production cell proliferation cell survival cellular chemotherapy cloning efficiency clonogenic cells colony cyclophosphamide cytotoxic agents Denekamp DNA synthesis dose epithelium estimates etal experimental tumours exponential growth fibrosarcoma G2 phase growth curve growth fraction growth kinetics growth rate human tumours implants injection intermitotic interval irradiation labelled cells labelled mitoses labelled-mitoses curve leukaemia leukaemic lung metastases lymphoma mammary tumours measured median melanoma metaphase method mice mitosis mitotic cycle mitotic index neoplastic non-proliferating cells normal tissues number of cells observed parameters patients peak phase durations produce proliferating cells radiation radioactivity rate of cell regrowth response S-phase sarcoma shown in Fig solid tumours stem-cells studies survival curves synchronized technique transplanted tumours treatment tritium tumour cells tumour growth tumour volume vinblastine vitro vivo volume doubling