Hematology: Clinical Principles and ApplicationsThis comprehensive text examines normal hematopoiesis through diseases of erythroid, myeloid, lymphoid and megakaryocytic origins. Hemostasis and coagulation theory, testing, and instrumentation are also thoroughly discussed. Beautiful full-color illustrations throughout the text enhance comprehension and allow students to realistically visualize hematology concepts. Detailed, full-color illustrations appear near hematology concept discussions to visually support comprehension and recognition.Opening Case Studies present real-life scenarios to apply concepts presented in each chapter.Learning Objectives and Review Questions work together to list expected outcomes and then test those concepts for each chapter.A Bulleted Summary highlights the key concepts at the end of each chapter.Hematology/Hemostasis Reference Ranges inside the front and back covers provide quick reference. Three new chapters detail significant information: An Overview of Clinical Laboratory Hematology, Hematology in Selected Populations, and Monitoring Anticoagulant Therapy.All chapters have been revised to feature the most current technology and research updates.The included Glossary of Terms and consistent pedagogy ensure a cohesive, effective tool for learning.Two well-respected editors contributed more significantly to this third edition: George Fritsma shared his expertise for the Hemostasis section and Kathy Doig managed the pedagogical features. |
Contents
Introduction to Hematology | 1 |
An Overview of Clinical Laboratory Hematology | 5 |
Safety in the Hematology Laboratory | 7 |
Specimen Collection | 17 |
Care and Use of the Microscope | 30 |
Quality Assurance | 39 |
Hematopoiesis | 50 |
Morphology and Function of Cellular Components | 51 |
Hemoglobinopathies Structural Defects in Hemoglobin | 333 |
Thalassemias | 355 |
Leukocyte Disorders | 373 |
Introduction to Leukocyte Neoplasms | 389 |
Cytochemistry | 398 |
Cytogenetics | 407 |
Molecular Diagnostics in the Clinical Laboratory | 424 |
Flow Cytometric Analysis in Hematologic Disorders | 451 |
Hematopoietic Theory | 57 |
Erythrocyte Production and Destruction | 77 |
Metabolism of the Erythrocyte | 94 |
Hemoglobin Metabolism | 105 |
Iron Metabolism | 116 |
Leukopoiesis | 124 |
Platelet Production Structure and Function | 141 |
Routine Laboratory Evaluation of Blood Cells | 160 |
Examination of the Peripheral Blood Smear and Correlation with the Complete Blood Count | 175 |
Bone Marrow Overview | 193 |
Body Fluid Examination | 205 |
PartV Erythrocyte Disorders | 219 |
Disorders of Iron and Heme Metabolism | 232 |
Anemias Caused by Defects of DNA Metabolism | 248 |
Bone Marrow Failure | 259 |
Introduction to Increased Destruction of Erythrocytes | 271 |
Intracorpuscular Defects Leading to Increased Erythrocyte Destruction | 286 |
Extracorpuscular Defects Leading to Increased Erythrocyte DestructionNonimmune Causes | 313 |
Extracorpuscular Defects Leading to Increased Erythrocyte DestructionImmune Causes | 325 |
Myeloproliferative Disorders | 471 |
Myelodysplastic Syndromes | 484 |
Acute Leukemias | 496 |
Mature Lymphoid Neoplasms | 506 |
Hematology in Selected Populations 541 | 526 |
Cell Counting Automation | 541 |
Hemostasis and Thrombosis | 571 |
Hemorrhagic Coagulation Disorders | 588 |
Thrombosis Risk Testing | 605 |
Thrombocytopenia and Thrombocytosis | 630 |
Qualitative Disorders of Platelets and Vasculature | 655 |
Laboratory Evaluation of Hemostasis | 670 |
Monitoring Anticoagulant Therapy | 700 |
Coagulation Instrumentation | 714 |
Appendix Material Safety Data Sheet 729 | 735 |
Glossary | 749 |
773 | |
788 | |
Common terms and phrases
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