Infectious Diseases of Humans: Dynamics and Control

Front Cover
OUP Oxford, Aug 27, 1992 - Medical - 757 pages
This book deals with infectious diseases -- viral, bacterial, protozoan and helminth -- in terms of the dynamics of their interaction with host populations. The book combines mathematical models with extensive use of epidemiological and other data. This analytic framework is highly useful for the evaluation of public health strategies aimed at controlling or eradicating particular infections. Such a framework is increasingly important in light of the widespread concern for primary health care programs aimed at such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis, and the advent of AIDS/HIV and other emerging viruses. Throughout the book, the mathematics is used as a tool for thinking clearly about fundamental and applied problems having to do with infectious diseases. The book is divided into two parts, one dealing with microparasites (viruses, bacteria and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. The book synthesizes previous work in this rapidly growing field (much of which is scattered between the ecological and the medical literature) with a good deal of new material.
 

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Contents

Microparasites
25
Biology of hostmicroparasite associations
27
statics
66
Static aspects of eradication and control
87
dynamics
122
Dynamic aspects of eradication and control
144
empirical evidence for
155
Agerelated transmission rates
172
dynamics
507
Acquired immunity
530
Heterogeneity within the human community
541
Indirectly transmitted helminths
550
Experimental epidemiology
590
Parasites genetic variability and drug resistance
607
The ecology and genetics of hostparasite associations
626
Appendices
657

Genetic heterogeneity
208
Social heterogeneity and sexually transmitted diseases
228
Spatial and other kinds of heterogeneity
304
Endemic infections in developing countries
319
Indirectly transmitted microparasites
374
Macroparasites
431
Biology of hostmacroparasite associations
433
statics
467
Dynamic properties of models for hostmicroparasite interactions
663
Agedependent transmission and WAIFW matrices
675
E Aspects of heterogeneities in hostmicroparasite interactions
684
G Optimal immunization programmes in heterogeneous populations
694
Author index
737
Subject index
747
Copyright

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About the author (1992)

Roy M. Anderson is at Imperial College, London. Robert M. May is at University of Oxford and Imperial College, London.