Mass Spectrometry: Analytical Chemistry by Open Learning
The second edition of this ACOL text, which was first published in 1987, continues to provide the analyst with an excellent introduction to mass spectrometry by the adoption of a practical approach in which the theoretical and operational aspects of this major analytical technique are combined. In the revised edition of this text, the author has expanded upon and reorganised the earlier material in order to bring it completely up to date. In addition to the basic theory of ion formation and behaviour, instrumentation and the interpretation of the spectra of simple organic compounds, this new edition reflects a number of the very important developments which have taken place in this field since the late 1980s. These include the burgeoning area of hyphenated mass spectral techniques, including gas chromatography-mass spectrometry (GC-MS), liquid chromatography-gas chromatography (LC-GS) and tandem mass spectrometry (MS-MS). Associated newer methods of interfacing, such as electrospray and ionspray, particle-beam and continuous flow coupling and atmospheric-pressure chemical ionisation are also covered. The current widespread use of computing techniques in structure elucidation is also considered, along with the important area of inorganic mass spectrometry for analysing surfaces, bulk solids and solutions. Analytical Chemistry By Open Learning This series provides a uniquely comprehensive and integrated coverage of analytical chemistry, covering basic concepts, classical methods, instrumental techniques and applications. The learning objectives of each text are clearly identified and the student's understanding of the material is constantly challenged by self-assessment questions with reinforcing or remedial responses. The overall objective of Analytical Chemistry by Open Learning is to enable the student to select and apply appropriate methods and techniques to solve analytical problems, and to interpret the results obtained. We are grateful to Dr Roger Taylor of the University of Sussex, UK for supplying the spectrum of fullerene used on the front cover.
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Ion Sources and Methods of lonisation
The Mass Spectrometer
Ion Detection Data Recording and Processing
Use of Isotopes in Mass Spectrometry
Metastable Ions and Modes of Fragmentation
Typical Fragmentation Patterns of Common Functional
Analysis of Mixtures by Hyphenated Mass Spectral
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a-cleavage accelerated acid alcohols aldehydes aliphatic alkene alkyl aromatic atomic mass base peak benzene ring benzyl bond calculate carbon CH3CH CH3CO chromatograph cleavage cluster common compounds containing daughter ions derivatised derivatives desorption detector elements equation esters even-electron field desorption formula fragment ions fragmentation pathways fragmentation pattern GC/MS give m/z heterolytic hydrocarbon hydrogen instrument intense interface ion beam ion source ionisation isomers isotope ketones kinetic energy LC/MS loss m/z Figure m/z values mass analyser mass spectrometry mass spectrum metastable metastable ions methanol method methyl molecular ion molecules obtained occur peptides phenyl positive charge positive ions produced proton quasi-molecular ion ratio rearrangement relative abundances relative molecular mass resolving power Response sample scan Schematic representation shown in Figure shows the mass solvent spectra spectrometer spectrum of Unknown stabilised stable Table tandem mass spectrometry technique thermospray tropylium voltage
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