Metabolic Engineering: Principles and Methodologies
Academic Press, Oct 17, 1998 - Technology & Engineering - 725 pages
Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes.
Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.
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Chapter 3 Comprehensive Models for Cellular Reactions
Chapter 4 Material Balances and Data Consistency
Chapter 5 Regulation of Metabolic Pathways
Metabolic Engineering in Practice
Chapter 7 Metabolic Pathway Synthesis
Chapter 8 Metabolic Flux Analysis
Chapter 9 Methods for the Experimental Determination of Metabolic Fluxes by Isotope Labeling ...