Motor Function of the Pharynx, Esophagus, and Its Sphincters

Front Cover
Morgan & Claypool Publishers, 2011 - Medical - 76 pages
Deglutition or a swallow begins as a voluntary act in the oral cavity but proceeds autonomously in the pharynx and esophagus. Bilateral sequenced activation and inhibition of more than 25 pairs of muscles of mouth, pharynx, larynx, and esophagus is required during a swallow. A single swallow elicits peristalsis in the pharynx and esophagus along with relaxation of upper and lower esophageal sphincters. Multiple swallows, at closely spaced time intervals, demonstrate deglutitive inhibition; sphincters remain relaxed during the entire period, but only the last swallow elicits peristalsis. Laryngeal inlet closure or airway protection is very important during swallow. Upper part of the esophagus that includes upper esophageal sphincter is composed of skeletal muscles, middle esophagus is composed of a mixture of skeletal and smooth muscles, and lower esophagus, including lower esophageal sphincter, is composed of smooth muscles. Peristalsis progresses in seamless fashion, despite separate control mechanism, from the skeletal to smooth muscle esophagus. The esophagus's circular and longitudinal muscle layers contract synchronously during peristalsis. Sphincters maintain continuous tone; neuromuscular mechanisms for tonic closure in the upper and lower esophageal sphincters are different. Lower esophageal sphincter transient relaxation, belching mechanism, regurgitation, vomiting, and reflux are mediated via the brain stem. Table of Contents: Introduction / Central Program Generator and Brain Stem / Pharynx-Anatomy, Neural Innervation, and Motor Pattern / Upper Esophageal Sphincter / Neuromuscular Anatomy of Esophagus and Lower Esophageal Sphincter / Extrinsic Innervation: Parasympathetic and Sympathetic / Interstitial Cells of Cajal / Recording Techniques / Motor Patterns of the Esophagus-Aboral and Oral Transport / Deglutitive Inhibition and Muscle Refractoriness / Peristalsis in the Circular and Longitudinal Muscles of the Esophagus / Neural and Myogenic Mechanism of Peristalsis / Central Mechanism of Peristalsis-Cortical and Brain Stem Control / Peripheral Mechanisms of Peristalsis / Central Versus Peripheral Mechanism of Deglutitive Inhibition / Neural Control of Longitudinal Muscle Contraction / Modulation of Primary and Secondary Peristalsis / Neural Control of Lower Esophageal Sphincter and Crural Diaphragm / Lower Esophageal Sphincter / Swallow-Induced LES Relaxation / Crural Diaphragm Contribution to EGJ and Neural Control / Transient LES Relaxation and Pharmacological Inhibition / Compliance of the EGJ / References
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Introduction
1
Central Program Generator and Brain Stem
2
PharynxAnatomy Neural Innervation and Motor Pattern
4
Upper Esophageal Sphincter
10
Neuromuscular Anatomy of Esophagus and Lower Esophageal Sphincter
14
Parasympathetic and Sympathetic
19
Interstitial Cells of Cajal
23
Recording Techniques
24
Peripheral Mechanisms of Peristalsis
37
Central Versus Peripheral Mechanism of Deglutitive Inhibition
40
Neural Control of Longitudinal Muscle Contraction
41
Modulation of Primary and Secondary Peristalsis
42
Neural Control of Lower Esophageal Sphincter and Crural Diaphragm
43
Lower Esophageal Sphincter
44
SwallowInduced LES Relaxation
49
Crural Diaphragm Contribution to EGJ and Neural Control
51

Motor Patterns of the EsophagusAboral and Oral Transport
27
Deglutitive Inhibition and Muscle Refractoriness
29
Peristalsis in the Circular and Longitudinal Muscles of the Esophagus
31
Neural and Myogenic Mechanism of Peristalsis
34
Central Mechanism of PeristalsisCortical and Brain Stem Control
35
Transient LES Relaxation and Pharmacological Inhibition
53
Compliance of the EGJ
55
References
57
Copyright

Other editions - View all

Common terms and phrases

Bibliographic information