Myalgic Encephalomyelitis and Postviral Fatigue States: The Saga of Royal Free Disease

abnormal activity acute aetiological affected agent Angeles antibody associated authors Beard became Behan British cells central nervous system changes chronic clinical co-workers common complete concentration considered consistent Coxsackie cranial nerve depression described developed diagnosis disease disturbance doctors Durban early emotional enzymes epidemic epidemic neuromyasthenia evidence examination extremities fatigue fatigue syndrome fever findings five followed four further headache hundred illness immune impairment important increased infection involvement Lancet levels limbs London marked mass hysteria McEvedy Medical Journal Medicine months muscle myalgic encephalomyelitis myelitis nerve neurological normal North noted nurses observed occurred onset organic outbreak pain patients period persistent physical poliomyelitis possible postviral fatigue present prolonged recorded recovery referred relapses reported response result Royal Free Hospital seen severe showed similar sporadic staff suggested symptoms syndrome tenderness term titres usually viral virus virus infection viruses weakness West