New Drug Discovery and DevelopmentA case history approach to drug synthesis and discovery Discover the origins of some of today’s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval. This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners. |
Contents
| 1 | |
2 Antiviral Drugs | 23 |
3 Antihypertensive Agents | 35 |
4 Lipid Lowering Drugs | 57 |
5 Centrally Acting Analgesics | 73 |
6 Nonopiate Analgesic Agents | 91 |
7 Steroids | 111 |
8 Histamine | 145 |
9 From Lab Bench to Pharmacy Shelf | 161 |
Appendix | 173 |
Index | 177 |
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Common terms and phrases
acid additional administered agents analgesic analogs androgens anti-inflammatory antibiotics antihistamines antihypertensive approved bacteria benzene ring beta-lactam biological blockers cancer carboxylic acid cause cell cephalosporins Chapter Chem chemical structure chemistry chemists cholesterol class of drugs clinical trials complex compound comprises congeners corticoids cortisone derivative disease dose double bond Drug Discovery drug substance early enzyme estrogen antagonists fact Figure five-membered ring function fused ring histamine hormones hydroxyl group included infected inhibit inhibitors involved known laboratories large number lead LEDNICER levels metabolism methyl group minoxidil mirror image forms modified molecule morphine nitrogen nonproprietary names NSAIDs nucleosides opiate oral contraceptives orally active organic organic chemistry oxygen penicillin Pharmacol pharmacological progesterone progestin prostaglandin protein receptors replaced result scientists screen showed side chain side effects starting material statins steroid steroid nucleus synthesis tablet testosterone toxicity treating treatment U.S. patent Upjohn virions Wiley
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