Platelet-Rich Plasma: Regenerative Medicine: Sports Medicine, Orthopedic, and Recovery of Musculoskeletal Injuries

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José Fábio Santos Duarte Lana, Maria Helena Andrade Santana, William Dias Belangero, Angela Cristina Malheiros Luzo
Springer Science & Business Media, Oct 29, 2013 - Technology & Engineering - 360 pages
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Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair.

This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In this sense, a feasible strategy for studying PRP preparation is illustrated, which also allows to modulate and tailor the quality of PRP for further clinical applications.

The science behind PRP and stem cells, on tissue regeneration, cell proliferation and mesenchyme stem-cells are emphasized and reviewed. Various specific uses of PRP are described with detailed illustrations of various personal experiences mainly in orthopedic injuries, ligament and tend

on repair, degenerative diseases, sports medicine, chronic wound healing as well as rehabilitation aspects in tendinopathy.

Expertly written by leading scientists in the field, this book provides for beginners and experienced readers scientific fundamentals, the state of art of PRP, specific uses and personal experiences with a practical approach and reference for current trends in use. Finally, this book paves the way for future developments.

 

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Contents

The State of the Art
1
Platelet Biology Growth Factors and a Review of the Literature
61
Practical Cellular Biochemistry for Regenerative Medicine
95
4 Challenges and a Feasible Strategy for Studies and Standardization of PlateletRich Plasma
119
5 PlateletRich Plasma and Tissue Engineering
139
Literature Review Evidence and Personal Experience
153
7 The Use of PRP Injections and Stem Cells in an Office Setting
171
8 Platelet Rich Plasma Practical Use in NonSurgical Musculoskeletal Pathology
187
11 Platelet Rich Plasma PRP in Osteoarthritis
231
12 PRP in the Ambulatory Therapy of Tendinopathy of the Elbow Knee and Foot
237
13 PlateletRich Plasma and Biocellular Grafts
249
14 Disc Regeneration with Platelets and Growth Factors
265
15 Use of PlateletRich Plasma PRP in Treating Chronic Wounds
281
16 The Use of PlateletRich Plasma in Orthopaedic Injuries
289
17 Rehabilitation After PlateletRich Plasma Injections for Tendinopathy
315
18 Platelet Rich Plasma on Pain Management
329

Clinical Experience
203
10 PlateletRich Plasma PRP in Ligament and Tendon Repair
215
Brazil iMOR Research Institute for Sports Medicine Orthopedics and Regeneration
339
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