Principles of Regenerative Biology

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Bruce M. Carlson
Elsevier, Oct 10, 2011 - Science - 400 pages
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With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers.
  • Creates a general understanding of one of the most fascinating and complex phenomena in biology
  • Discusses the ability and diversity of regeneration in various organisms
  • Explains the history and origins of cells in regenerating systems
  • Includes information on stem cells and its important role in regeneration

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An Introduction to Regeneration
Origins of Cells in Regenerating Systems
Role of the Substrate in Regeneration
Tissue Interactions in Regeneration
Role of the Nerve in Regeneration
Morphogenesis of Regenerating Structures
Reintegrative Processes in Regeneration
Regeneration and Aging
Influence of the Environment on Mammalian Regeneration
Stem Cells Plasticity and Regeneration
Tissue Engineering and Regeneration
Stimulation of Regeneration
What Have We Learned and Where Are We Going?

Regeneration and Embryonic Development

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Page 353 - Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
Page 343 - Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.
Page 364 - Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, Scott EW: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Page 330 - Iten. 1976. Supernumerary limbs in amphibians: Experimental production in Notophthalmus viridescens and a new interpretation of their formation. Dev Biol 50:212-234.
Page 345 - Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999; 96:10711-10716.
Page 327 - Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA 85:2161.
Page 347 - The effect of regional gene therapy with bone morphogenetic protein-2-producing bonemarrow cells on the repair of segmental femoral defects in rats. J. Bone Joint Surg. Am.
Page 348 - Phenotypic modulation of endothelial cells by transforming growth factor-b depends upon the composition and organization of the extracellular matrix. J Cell Biol 1993; 106:1375-1384.
Page 345 - Korbling M, Katz RL, Khanna A et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002;346:738-46.

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