Radiobiology for the RadiologistThe updated Sixth Edition of this popular text will remain the first choice for those who need current, clinically relevant information on how radiation affects the human body. Written by practicing, active radiobiologists, the book brings together basic laboratory research and practical, clinical applications. The easy-to-read text and informative illustrations ensure comprehension, and summaries at the end of each chapter facilitate quick review. The first section covers topics applicable to diagnostic radiology, nuclear medicine, and radiation oncology; the second section offers material specifically for radiation oncologists. This edition includes new material about doses and risks in interventional radiology and cardiology. |
Contents
Milestones in the Radiation Sciences | 1 |
Physics and Chemistry of Radiation Absorption | 5 |
DNA Strand Breaks and Chromosomal Aberrations | 16 |
Cell Survival Curves | 30 |
Radiosensitivity and Cell Age in the Mitotic Cycle | 47 |
Repair of Radiation Damage and the DoseRate Effect | 60 |
Oxygen Effect and Reoxygenation | 85 |
Linear Energy Transfer and Relative Biologic Effectiveness | 106 |
Molecular Techniques in Radiobiology | 240 |
Cancer Biology | 274 |
DoseResponse Relationships for Model Normal Tissues | 303 |
Clinical Response of Normal Tissues | 327 |
Model Tumor Systems | 349 |
Cell Tissue and Tumor Kinetics | 363 |
Time Dose and Fractionation in Radiotherapy | 378 |
Predictive Assays | 398 |
Acute Effects of TotalBody Irradiation | 117 |
Radioprotectors | 129 |
Radiation Carcinogenesis | 135 |
Hereditary Effects of Radiation | 156 |
Effects of Radiation on the Embryo and Fetus | 168 |
Radiation Cataractogenesis | 181 |
Doses and Risks in Diagnostic Radiology Interventional Radiology and Cardiology and Nuclear Medicine | 187 |
Radiation Protection | 224 |
SECTION II | 226 |
Common terms and phrases
activity acute agents apoptosis assay atomic biologic effect breast cancer Cancer Res carcinoma cell cycle cell killing cell lines cell survival cellular chemotherapy chromosome clinical clonogenic cyclin cytotoxic dose fractions dose rate dose-response dose-response relationship drug effective dose energy exposure factor FIGURE function G₁ gene genetic genome growth head and neck heat human tumors hyperthermia hypoxia hypoxic cells ICRP increase Int J Radiat ionizing radiation irradiation labeled late effects lethal leukemia low doses lung malignant mammalian cells misonidazole mitosis mitotic molecule mouse mutations neutrons normal tissues nuclear oncogene Oncol Biol Phys oxygen patients phase population produce proliferation protein protons Radiat Oncol Biol Radiat Res radiation dose radiation therapy radiation-induced radioactive Radiol Radiology radiosensitivity radiotherapy repair response risk sarcoma sensitive sequence skin stem cells sublethal damage survival curve surviving fraction tion tirapazamine treatment tumor cells vitro vivo x-rays y-rays
