Schaechter's Mechanisms of Microbial DiseaseMoselio Schaechter, N. Cary Engleberg, Victor J. DiRita, Terence Dermody Now in full color, the Fourth Edition of this text gives students a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text facilitates learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. Case studies with problem-solving questions give students insight into clinical applications of microbiology. Each chapter ends with review and USMLE-style questions. For this edition, all schematic illustrations have been re-rendered in full color and new illustrations have been added. A new online site for students includes animations, USMLE-style questions, and all schematic illustrations and photographs from the text. |
Contents
Establishment of Infectious Diseases | 3 |
Normal Microbial Flora | 11 |
Biology of Infectious Agents | 18 |
Genetic Approaches to Studying Bacterial Pathogenesis | 39 |
SECTION 2 | 42 |
Biological Basis for Antibacterial Action | 56 |
Innate Immunity | 66 |
Adaptive Immunity | 90 |
A Disease With a History | 263 |
Borrelia burgdorferi and Lyme Disease | 271 |
Cat Scratch Disease Bacillary Angiomatosis and Other Bartonelloses | 280 |
Picornaviruses and Coronaviruses | 324 |
Measles Virus and Respiratory Syncytial Virus | 347 |
Rabies | 357 |
Influenza and Its Viruses | 363 |
Rotaviruses Noroviruses and Other Viral Agents of Gastroenteritis | 370 |
The Parasites Way of Life | 116 |
Damage by Microbial Toxins | 126 |
Infectious Agents | 139 |
BACTERIA 10 Introduction to the Pathogenic Bacteria | 141 |
Abscesses and ToxinMediated Diseases | 147 |
Sore Throats and Beyond | 156 |
Pneumococcus and Bacterial Pneumonia | 164 |
Gonococcus and Meningococcus | 173 |
Bacteroides and Abscesses | 183 |
Secretory Diarrhea | 190 |
Bloody Diarrhea and Dysentery | 200 |
A Ubiquitous Pathogen | 215 |
Bordetella pertussis and Whooping Cough | 223 |
Diarrheal Disease Tissue Infection Botulism and Tetanus | 230 |
Parasite of Amebas and Macrophages | 236 |
Pathogenesis of a Slow Bacterial Infection | 243 |
Tuberculosis and Leprosy | 251 |
AIDS and Other Diseases | 376 |
Adenoviruses | 389 |
Human Papillomaviruses and Warts | 399 |
Herpes Simplex Virus and VaricellaZoster Virus | 406 |
Cytomegalovirus | 415 |
Viral Hepatitis | 424 |
Antiviral Treatment Strategies | 435 |
Vaccines and Antisera for the Prevention and Treatment of Infectious Diseases | 445 |
SECTION 3 | 451 |
PARASITES | 480 |
Blood and Tissue Protozoa | 489 |
Intestinal and Vaginal Protozoa | 504 |
Intestinal Helminths | 513 |
Tissue and Blood Helminths | 524 |
SECTION 5 | 536 |
Common terms and phrases
abscess acid activation adaptive immune adaptive immune system aeruginosa agents anaerobic antibiotics antibodies antigen antimicrobial aureus bacteria bacterium binding blood cell surface cellular Chapter cholera chronic clinical coli colonization common complement complex contain culture cytokines cytoplasm damage defenses developed diagnosis diarrhea drugs encode enzymes epithelial cells exotoxins expression factors fever FIGURE function genes genome gonococci Gram-negative Gram-positive host cell human immune response immune system immunoglobulin induced infection inflammation inflammatory influenza inhibit innate immune innate immune system intestinal intracellular kill lesions Lyme disease lymphocytes macrophages measles mechanisms membrane MHC class microbes microorganisms molecules mucosal mutants neutrophils normal occurs organisms pathogens pathway patients penicillin peptides phagocytes phagocytosis plasmid pMHC pneumonia pneumophila prevent produce proteins pylori receptors replication resistance respiratory result Salmonella secretion serotypes Shigella skin specific spirochete spread strains streptococci symptoms synthesis syphilis therapy tion tissues toxin tract transmission tuberculosis vaccine viral virulence virus viruses