This book is concerned with the biosynthesis, biological activity, and ecological significance of secondary metabolites (natural products).These include alcaloids such as morphine, steroids like cholesterol, and antibiotics like the penicillins. The author considers each of the major classes of secondary metabolites according to the basic 'building blocks' from which they are derived and highlights the pharmacological and toxicological properties of compounds found in insects, plants, and microorganisms. The final chapter explores the possible ecological significance of these products. The second edition incorporates new material on the isolation and characterization of the enzymes of secondary metabolism and on the new NMR techniques which have revolutionized the elucidation of biosynthetic pathways. The book is important reading for advanced undergraduates and graduates in chemistry, biochemistry, and botany, as well as researchers in the pharmaceutical industry.
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Saturated fatty acids Unsaturated fatty acids The polyacetylenes
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acetyl-SCoA active alkaloids alkylation amino acids antibiotics ArC1 aromatic biogenesis biogenetic biological biosynthetic biosynthetic pathway C2 units carbon atoms cardenolides CH2OH Chem chemical chemistry cholesterol cinnamic acid CO2H CO2H CO2H compounds COSCOA coupling cyclization degradation derived from acetate derived from shikimate DMAPP enzyme esters example fatty acids flavonoids formed fungal higher plants HO2C hormones hydrogen incorporated insects interactions intermediate isoprene isoprenoids known labelling pattern lysine mediated metabolic pathways methyl groups mevalonate mode molecules monoterpenes natural products nucleophilic occur OH CO2H OH O OH OH OH organisms oxidative oxygen peptide phenols phenylalanine pheromones polyketide polyphenols precursor probably produced prostaglandins pyrophosphate reactions recently ring S-adenosyl methionine SCoA secondary metabolites sesquiterpenes shikimic acid shown in equation shown in Fig side-chain skeletal types skeletons species squalene steroids sterols structural sub-unit substrate synthesized terpenes tion toxic tracer triterpenes tryptophan tyrosine utilized vitamin