Vaccine Adjuvants: Preparation Methods and Research Protocols
Derek T. O’Hagan
Springer Science & Business Media, Apr 15, 2000 - Medical - 342 pages
Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.
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acid adjuvant activity adjuvant effect adjuvant formulation adjuvanticity adsorbed adsorption alum aluminum adjuvants aluminum hydroxide aluminum phosphate animal antibody antibody response antigen aqueous assay biological buffer cells clinical cochleates concentration containing copolymer cytokine cytotoxic delivery detergent dialysis diluted diphtheria toxoid dose ELISA emulsion endotoxin enhance entrapped epitopes filter Freund’s glycoprotein Gregoriadis guinea pigs hepatitis human immune response immunogenicity Immunol immunological adjuvant Incubate induced influenza virus injection interleukin intranasal IRIV ISCOM-matrix ISCOMs lipid liposomes membrane Methods mg/mL mice Microfluidizer microparticles mineral oil molecular Morein mucosal nanoparticles O’Hagan oligos oral particles peptide plasmid PMMA polymer polymerization preparation production Proleukin protective protein Protocols Quillaja recombinant safety saline sample saponin serum sodium soluble solution sterile stimulation studies Subheading subunit vaccine Table temperature tetanus toxoid tion toxicity tube Ty-VLPs Vaccine Adjuvants vaccine antigens vaccine formulation vesicles vial viral virosomes