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actin activity addition analysis animal applications areas associated authors biology candidates cells Centre climate close complex containing contribute COP1 core Correspondence culture Department detection determined disease drug effects example experience expression factor field Figure function funding further gene genetic genome growth human increase indicate individual Institute interactions interests involved laboratory leading levels materials measured mechanism Methods molecular Nature observed obtained organisms performed plants pollen populations position potential predicted present production protein publishing range record region regulation response role says Science scientific scientists selection sequence shown signal single species structure successful suggest Supplementary surface temperature transcription United University Western blot