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actin activity addition analysis animal applications areas associated authors B-cells biology candidates cells Centre climate close complex containing COP1 core corresponding culture Department detection determine disease drug effects et al example experience expression factor field Figure function funding further gene genetic genome growth human important increase indicate individual Institute interactions interests International involved laboratory leading levels limited materials measured mechanism Methods molecular Nature observed obtained organizer performed plants pollen population position potential predicted present production protein publishing record region regulation response role says Science scientific scientists selection sequence shown signal single species structure successful suggest Supplementary surface temperature transcription University western blot