Nature, Volume 429 |
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Page 88
WB : Flag WB : p53 WB : actin ง Relative p53 mRNA levels 1.21 11 h WB : Flag 0.8 0.61 0.4 0.2 WB : p53 WB : actin Flag vector I COP1 Flag - COP1 • C C C C Vector + ALLN Flag vector COP1ARING COP1ARING Flag vector COP1 COP1 Flag ...
WB : Flag WB : p53 WB : actin ง Relative p53 mRNA levels 1.21 11 h WB : Flag 0.8 0.61 0.4 0.2 WB : p53 WB : actin Flag vector I COP1 Flag - COP1 • C C C C Vector + ALLN Flag vector COP1ARING COP1ARING Flag vector COP1 COP1 Flag ...
Page 89
Furthermore , COP1 was able to decrease the steady - state levels of endogenous p53 in U2 - OS cells ( Fig . 2b ) . To gain further insight into the mechanism of this reduction in p53 protein levels , real - time PCR was carried out on ...
Furthermore , COP1 was able to decrease the steady - state levels of endogenous p53 in U2 - OS cells ( Fig . 2b ) . To gain further insight into the mechanism of this reduction in p53 protein levels , real - time PCR was carried out on ...
Page S-13
Epidemiological studies and large - scale clinical trials with the statin class of cholesterollowering drugs have conclusively shown an association between reduced levels of lowdensity - lipoprotein cholesterol ( LDL - C ) and decreased ...
Epidemiological studies and large - scale clinical trials with the statin class of cholesterollowering drugs have conclusively shown an association between reduced levels of lowdensity - lipoprotein cholesterol ( LDL - C ) and decreased ...
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actin activity addition analysis animal applications areas associated authors B-cells biology candidates cells Centre climate close complex containing COP1 core corresponding culture Department detection determine disease drug effects et al example experience expression factor field Figure function funding further gene genetic genome growth human important increase indicate individual Institute interactions interests International involved laboratory leading levels limited materials measured mechanism Methods molecular Nature observed obtained organizer performed plants pollen population position potential predicted present production protein publishing record region regulation response role says Science scientific scientists selection sequence shown signal single species structure successful suggest Supplementary surface temperature transcription University western blot