FIG.

CASE IX.-Chronic Albuminuria; fatal, p. 126.

1.- Urine, orange coloured, abundance of lithates, highly albuminous. Casts partly transparent, partly granular; highly resplendent free nuclei dispersed through them; many nuclei aggregated together, without a cell-wall.

2.-Casts very transparent; many free nuclei; at the extremity of one, numerous fat-granules and grape-like clusters of nuclei without a cell-wall. 3. Casts slightly granular, a crystal of lithic acid imbedded in one; many free nuclei, both in the casts and scattered over the field. Casts studded with granule-cells.

4.-Casts more or less transparent; several very large compound granule-cells; free nuclei in abundance, and grape-like clusters of nuclei without a cellwall. The granular matter occurred chiefly in contiguity with the free nuclei, arising probably from the breaking-up of abortive cells.

5.-The casts very transparent, containing a few free nuclei, small granule-cells, and nuclei aggregated together without a cell-wall.

6.-Casts very transparent and faint; many free nuclei in grape-like clusters, and large compound cells; many aggregate nuclei without a cell-wall.

7. Casts very transparent; compound granule-cells, very large.

a, a.—The cell-wall apparently just ruptured.

Pavement-epithelium very granular.

8.-Casts very delicate and translucent; free nuclei and large compound granule-cells.

a, a, a.-The cell-wall of more than one of these appears just ruptured, as in fig. 7 and the contents of the cell, as of some viscid material like mucus, seemed drawn out in an elongated film.

:

CASE XXV.-Relation of Bright's Disease to Phthisis, p 221.

9.-Hyaline casts, with free nuclei, fat-grains, and abortive epithelium. A week before death.

10.-Fluid squeezed out by pressure from one of the cones; various forms of epithelium-a, a, from the straight tubes,-b, b, from the calyces, many free nuclei, and compound fat-cells.

11.-Tubes from the apex and base of one of the cones; a and b are the same tube from the apex, under variations of focus-the canal seems to contain many free nuclei; c is a tube from the base of the cone. The epithelial cells in spots are detached from the basement membrane, the canal seems obstructed by granular matter, free nuclei, and abortive cells; d, d, are epithelial cells from the straight tubes becoming fatty and abortive.

12. The appearance presented by a section of one of the more prominent and larger granulations of the surface of the kidney. The Malpighian bodies appear choked with granular matter, free nuclei, fat-grains, and abortive epithelium, and to be imbedded in a fibrilloid matter which might be viewed as new product.

13.-Appearance of the soft central portion of the yellow deposit in one of the cones. Large compound cells, much free fat, granular matter, and abortive cells, such as are usually seen in softening tubercle.

14.-Muscular fibre from the left ventricle, partly fatty and degenerating.

PLATE VII.

CASE XXVI.-Relation of Bright's Disease to Phthisis, p. 225.

FIG.

1. Urinary deposit composed of faintly granular casts, containing free nuclei, abortive or atrophic epithelial cells, vesical epithelium, fatty; a large compound cell (Gluge's corpuscle), and a crescentic group of granules.

2. Urinary deposit seven days later. Finely granular tubes containing much free fat and fatty cells. Epithelium of the pelvis and bladder implying fatty decay.

3.-Mucoid or viscid deposit a few days later, composed of masses of several varieties of epithelial cells, all having the appearance of fatty decay.

a, a, a.-Squamous epithelium from the bladder.

b, b.-Epithelium from pelvis of the kidney. c, c.-Abortive epithelial cells.

d.-Glomerulus or compound fat-cell.

e.-Crystals of lozenge-shaped uric acid.

A great deal of free fat and granular matter dispersed over the field.

4.-Deposit within the last week of life.

a.-Large compound fat-cells, disintegrated or broken up.

b.-Abortive and fatty epithelial cells.

c.-A cast highly fatty, even oily; one or more crystals of uric acid present. Post-mortem.

5.-One of the wax or spermaceti-like grains on the cortical surface of the kidney.

a.-Large compound cells, some broken up.

b.-Abortive and fatty epithelial cells.

c.-Free fat-granules mixed with oily drops and amorphous granular matter dispersed over the

field.

6. One of these minute spermaceti-like granules carefully picked out. The convoluted tubular structure was still obscurely visible; the whole appeared a dense deposit of fat-grains and granular matter; some large compound cells were visible.

7.-Microscopic appearance of one of the striated wax-like like lines of the cortical part, its direction perpendicular to the surface.

a. The appearance was that of a tube filled with free fat, and abortive and fatty epithelium. b.-A tube containing nothing but free fat and granular matter.

8.-Tubes teazed out from the mammary cones.

a. From the base of the cone. A tube filled with compound cells, abortive and fatty epithelium, free fat, and granular matter.

b.-A tube from the apex of the cone. The appearances differ but little from the healthy structures. The canal seems filled with fat-cells and granular matter, but the epithelium of the tube appears not to have passed into the stage of fatty degeneration, save in one or two of the cells.

9.-Muscular fibre of left ventricle, fatty and degenerate.

CASE X.-Chronic Albuminuria, Nodulated Kidney; fatal,

p.
130.

10. Convoluted tubes from base of one of the cones. Some epithelial cells are detached from the basement membrane, and appear imbedded in granular matter and free nuclei; others appear unchanged and still adherent to the tube.

11, 12.-A vertical section of one of the tubercles on the surface of the kidney. Fig. 11 is probably a dilated Malpighian tuft, filled with granular matter and free fat-grains. Convoluted tubes filled with the same material.-Fig. 12 shews convoluted tubes filled with the same.

13.-A portion of the denser part of the cortex, teazed out with needles. The appearance is that of a tubular structure, empty, flattened, condensed, &c.

14.-A section of the more dense part at the base of one of the cones. It exhibits the character of a fibrous stroma, a portion having the appearance of condensed and atrophied tubular structure. A good deal of free fat was dispersed through it.

15.-A part of the least condensed portion of the last section, teazed out with needles. The appearance is that of an original tube-structure, as at fig. 13, flattened and ribbon-like. A few isolated nuclei and some fat-granules are apparent, but all vestige of the epithelial structure lining the tubes is lost.