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acid activity analysis antibodies apoptosis applications AQPO assays asteroids B-cells bioinformatics Biol biotechnology cancer candidates caspase Cell Biology cellular centre climate clinical cloning COP1 core culture Department detection disease domain drug e-mail effects experience expression field function funding galectin-2 gastrula gene genetic genome global granule cells growth human increase indicate Institute interactions Japan laboratory ligand magnetic mammalian MDM2 MDMA mechanism membrane mice molecular biology molecules mouse mutant nature publishing group Naturejobs neurons Neuroscience nuclear observed ocean ORF2 oxygen photons Phys pollen pollen tubes position postdoctoral potential predicted production protein proteomics rats receptor recruitment region response retrotransposition retrotransposon ribozyme RN-tre says Science scientific scientists sequence signal siRNA species stem cells structure Supplementary Fig surface target temperature tissue transcription transfected transgenic University wild-type www.nature.com/nature