stop here and give nothing else, the Glanderine would go on acting, and conduct the case to a successful result.

In catarrh, as in bronchitis, and especially where the symptoms are grievous, and the nose inflamed with thick and tinged defluxion, where the tonsils are swollen and the fauces gorged, you will be surprised by the rapidly specific action of Glanderine. If the nose and mouth are ulcerated, so much the better for the energy of its characteristic action.

In terrible cases of scarlatina, where the odour of the breath is putrid, and the buccal passages are filled with tenacious lymph and mucus, while the swollen tonsils close the posterior channels, this remedy alone, from its wonderful promptitude, seems capable of rescuing the patient. I have tried it in none such; but that it would not disappoint experiment, is a fair deduction from what it can do. Recently, it saved a little patient apparently suffocating from diphtherite in the mouth and nose, and agonised with buccal ulcerations; in twelve hours the morbid secretion had ceased, and disappeared; the superficial ulcerations had vanished; and none of these symptoms reappeared.

It has been tried in putrid fever with the most marked and rapid success indeed, I should say that putrescence, destructive or quasi-malignant ulceration, and tendency to decomposition of the tissues, are among prime indications for its employment. It is well worth a trial in carbuncle and plague.

I have given it in one case of ozæna with marked success: and should constantly rely upon it in malignant erysipelas, particularly if attended with large formations of pus, and destruction of parts. In malignant pustule, which nearly resembles the disease that inoculated glanders produces in the human subject, I believe it would be specific. In pyema, and inflammation of the veins and lymphatics, particularly where matter is formed, or forming, Farcine would no doubt prove homœopathic, i. e. curative to the symptoms.

In the more violent or rapid cases, I would recommend the Glanderine, or Farcine, to be as recent as possible.

In malignant external ulcerations, I have used a lotion prepared by dissolving one two-grain pellet of Glanderine in half a tumblerful of water. Try the remedy thus in old bad legs, and

in putrid bed sores. It also deserves experiment in obstinate syphilitic sores attended with great fœtor; it will probably abate the malignancy of the inflammation, even if it cannot, from specific causes, work a deeper effect.

It is a fair deduction also, that Glanderine is a first-class remedy in confluent small pox, or it might be given in alternation with Farcine.

I have made no trials of it in skin-diseases; but shall assuredly do so wherever malignancy and phagedæna are prominent characteristics. It is promising in pustular ringworm.

I have cured one case of anasarca of the lower limbs with Farcine. This remedy, judging by the analogous effects in the horse, will probably apply with efficacy to uterine phlebitis. It is worth thinking of also in psoas and lumbar abscess.

Let the veterinarian try it in the lung disease, and murrain, of cattle.

A most interesting problem occurs: What will Glanderine do for phthisis? I can only answer that in my experience, it has stormed the outworks of phthisis; but whether it will carry the citadel remains to be proved. It diminishes the expectoration; abates the constantly recurring aggravations of inflammation; and checks the liability to catarrhal affections, which excite the tuberculous diathesis from without; but whether or no it will operate upon tubercle, I cannot say. In time, it is my intention to lay this matter in detail before the world; but at present a sufficient time has not elapsed to test the trueness of the remedy. Meanwhile I commit the experiment also to all humane persons, and institutions for the consumptive. The Glanderine can be given in alternate doses with iron, or other remedies being an animal substance, it will be singularly little interfered with by other drugs, provided three, four, or six hours intervene between the administration of the two substances.

The use of Glanders suggests also the use of all the other animal poisons. These indeed may be regarded as malignant or medicinal growths upon the fields of morbid animal nature, corresponding to the nefarious plants, aconites, upases, deadly nightshades, which grow upon the soil. We shall have to enter this field; for the very malignity of the poisons shows the

energy with which they will work for us when they are duly broken in. I shall now conclude by showing how safely all these poisons may be employed; and that they may be at the disposal not merely of the few, but of every one who will take the care and trouble of preparing them. For the cost of a few shillings, a whole county may receive the benefit of these remedies for a twelvemonth; and any humane person, medical, clerical, or common, may have the Christian privilege of dispensing them.

The following theory has sketched itself out for me relative to the action of Glanders, which, to save words, I state affirmatively.

This poison is actively centrifugal, and tends to abolish the centres of vitality by powerful ejection of their minutest contents the spaces being filled up with matter, the result of malignant or destructive inflammation. It is the type of vital destructions; and begins its ravages in the nose of the horse, because that is the spot where it can most easily explode its first seeds of disease: it wants space for throwing off and sowing its poison. It is good in all malignant ulceration and excessive expectoration. And its general curative indication is, wherever extrusion of contents overbalances supply of nutrition. It is the opposite to arsenic, which corrodes by stopping function, and isolating parts; this over-energises, explodes, and scatters the grains of living organisms.

Farcy is the same thing in parts where expulsion cannot go on; in which case destruction and retention of the destroyed parts have place. The lymphatic system is attacked, because it is the nutrient or supplying system, and it is affected by reaction. Glanders is the direct action; Farcy the inverse.

Now to obviate the objection of danger, as well as to disseminate and laicize the remedy, I will state the mode of preparation; premising that I have taken Glanderine myself for obstinate catarrh, and with only beneficial results.

By the aid of an experienced Veterinary Surgeon (I have enjoyed the invaluable kindness in this respect of Professor Spooner, Principal of the Veterinary College), procure in small onedrachm bottles the matter from the nose, and from the lungs, of infected horses immediately after their destruction. The Glan

derine from the nose and from the lungs, and the Farcine, should be of course in separate bottles. And each medicament, for we will no longer call them poisons, should be prepared separately. Let us now follow the nose Glanderine as a model for the rest through the various stages of its preparation.

Put on a pair of kid gloves.

Weigh ten grains of the Glanderine in glass scales: weigh in the same, ninety grains of thick gum mucilage. Rub the two together for twenty minutes, or until the amalgamation is complete. Then for the second time weigh ten grains of the new mixture; and throw away the rest. Let the mortar be carefully rinsed with large quantities of water at a sink where there is a ready outflow; and take heed to your eyes, or to any sore or cut surfaces, while you are engaged with the first dilutions of the Glanderine. Rinse lastly with boiling water, and cool the mortar again at the tap. Observing this caution, now rub the second ten grains with another ninety grains of thick mucilage; and of this mixture preserve one fluid drachm, throwing away the rest; and rinsing the mortar again with the same care. Now take your measured drachm of the second dilution of Glanderine, and in a two-ounce bottle, pour upon it nine drachms of distilled water. Cork the bottle, and put on the cork the figure 3, signifying the third dilution. Shake the bottle until its contents are thoroughly mixed. Into another two-ounce bottle now put one measured drachm of n. 3, and nine drachms of distilled water. Mark this n. 4, and shake it into admixture as before. Throw away the remaining nine drachms of n. 3. Then prepare n. 5, by a similar process to n. 4, and throw away the residue of n. 4. Perform all these operations neatly and gently, and mind your eyes in the meantime.

Now this is what you are to do with n. 5. Take an ounce of it by weight, and nine ounces of the best powdered gum arabic; mix them together in a mortar until the fluid is taken up, and the mass thoroughly amalgamated. That mass is your stock of harmless Glanderine of the sixth dilution. By carrying the process with the distilled water onwards, you can ci course make what further dilutions you please; but I have always made use of the sixth in my practice. Some of my

brethren will probably enrich experience by the employment of the 200th.

Well, you have got your mass; and now all you have to do, is, to make it into small pills. I make up two grains into a pill. The whole mass should be pillulated at once; and the pilules received into a flat box with plenty of sugar of milk at the bottom; and freely moved about many times for a few days to prevent them from sticking together. The medicine is now hermetically enclosed in the gum, and will preserve its virtues for months; perhaps for years.

How safe is its administration! The sixth attenuation contains in one grain but one millionth of a grain of the Glanderine, and this millionth is extended through a million fold its own space. My habit is to dissolve one of these pilules in half a tumblerful of water; and to direct a teaspoonful to be taken every four or every six hours. Thus again the dilution and extension are multiplied twenty-fold. Or in round numbers, each teaspoonful contains the twenty millionth of a grain, one thousand million times extended. The tumbler ought to be kept in a cool place, because the water easily ferments in warm weather.

So much for dilution of virus: now for experience of safety. I have on many occasions applied the contents of the tumbler to raw surfaces; have thrown it up the nose in ozæna; and given it in aphthæ and buccal ulcerations; and with only beneficial results.

Glanderine is not a pleasant idea: but neither is Vaccine: the healing use has however another idea concealed within it; and with this use alone the name of Glanderine will soon be associated.

HYGIENE IN RELATION TO PRIVATE BOARDING SCHOOLS.

BY GEORGE WYLD, M.D.,

One of the Committee on Sanitary Science at the Society of Arts. THE incomparable Nicholas Nickleby history is said to have brought to a speedy bankruptcy many a "Dotheboys Hall," and,