CRC Desk Reference for Allergy and AsthmaHans-Uwe Simon As the prevalence of allergic diseases and asthma has increased in recent years, scientists have intensified research efforts to understand the pathogenesis of these sometimes debilitating conditions. Indeed, researchers have provided key insights-and new concepts-that have changed therapeutic strategies. Moreover, allergic inflammation has served |
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activated T cells adhesion molecules airway hyperresponsiveness airway obstruction allergen allergen challenge allergic diseases allergic inflammation antibodies antigen antigen-presenting cells antigen-presenting cells APCs apoptosis associated atopic dermatitis basophils binding caspases cause CD4+ T cells CD8+ cell activation cell antigen receptor chemokines chronic clinical cloning co-stimulation Coombs and Gell corticosteroids cytokine gene cytokine receptors delayed hypersensitivity dendritic cells differentiation dose drugs effects endothelial cells enzyme eosinophils epitopes exposure expression function Gell classification genetic GM-CSF granules granulocytes high-affinity IgE receptor histamine house-dust mite immune responses immunoglobulin immunosuppressive immunotherapy increased induce infection inflammatory cells inhaled inhibition inhibitors interactions intracellular leukocytes leukotrienes ligand lung lymphocytes macrophages mast cells mechanisms mediators MHC class monocytes Moreover neutrophils NK cells pathways peptide phenotype pollen production proteases proteins release respiratory rhinitis role sensitization sequence signal transduction smooth muscle specific stimulation surface molecules symptoms syndrome Th2 cells Th2 cytokines therapy tissue transcription factors urticaria