Genetic Engineering: Principles and Methods, Band 23

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Jane K. Setlow
Springer Science & Business Media, 31.08.2001 - 232 Seiten
Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4).
 

Inhalt

EVOLUTION OF TRANSPORT PROTEINS
xviii
MECHANISMS OF APOPTOSIS REPRESSION 1
xxviii
CYTOKINE ACTIVATION OF TRANSCRIPTION
lviii
VECTOR DESIGN AND DEVELOPMENT OF HOST SYSTEM
11
GENETIC AND BIOCHEMICAL STUDIES ON THE ASSEMBLY OF
24
ENZYME AND PATHWAY ENGINEERING FOR SUICIDE GENE
90
THE ROLE
53
EXPRESSION OF FOREIGN GENES IN TIIE YEAST Pichia pastoris
115
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Autoren-Profil (2001)

Jane K. Setlow, PhD. has championed the field of genetics for over 30 years, agreeing to edit Genetic Engineering: Principles & Methods since its inception in 1979. An internationally recognized scientist with numerous publications, Dr. Setlow is the former Chairperson of the NIH Recombinant DNA Molecule Advisory Committee (RAC). Her lab can found at Brookhaven National Laboratory, Upton, New York.

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