Cytochrome P-450Paul Ortiz De Monetllano Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists. |
Other editions - View all
Cytochrome P-450: Structure, Mechanism, and Biochemistry Paul Ortiz De Monetllano Limited preview - 2013 |
Cytochrome P-450: Structure, Mechanism, and Biochemistry Paul Ortiz De Monetllano No preview available - 2013 |
Common terms and phrases
Acta ACTH activity adrenodoxin alkylation amino acid aromatase aromatic Biochem Biochemistry Biol Biophys biosynthesis bleomycin bond camphor carbon catalyzed cells characterization Chem cholesterol cholesterol side-chain cleavage cloned complex compounds Coon cumene cytochrome c peroxidase cytochrome P-450 dioxygen electron transfer electron transport enzyme epoxidation fatty acid ferric ferrous formation forms of P-450 gene heme hemeprotein hepatic hepatic microsomal high-spin hydrogen hydroperoxide hydrophobic hydroxylation inactivation induced inhibition inhibitors interactions intermediate iron isolated isotope effects isozymes kinetics ligand lipid liver microsomal cytochrome low-spin mechanism membrane metabolism microsomal cytochrome P-450 mitochondrial molecular molecule monooxygenase mRNA NADH NADPH NADPH-cytochrome Natl olefins oxidation oxygen P-450 isozymes P-450 reductase peptide peroxide Pharmacol phenobarbital phospholipid porphyrin prosthetic heme protein purified rabbit isozyme rabbit liver radical rat liver microsomes reaction receptor reconstituted redox reduced residues sequence specific spectral spin steroid hydroxylases steroidogenic structure studies synthesis turnover vesicles