Secondary MetabolismThis book is concerned with the biosynthesis, biological activity, and ecological significance of secondary metabolites (natural products).These include alcaloids such as morphine, steroids like cholesterol, and antibiotics like the penicillins. The author considers each of the major classes of secondary metabolites according to the basic 'building blocks' from which they are derived and highlights the pharmacological and toxicological properties of compounds found in insects, plants, and microorganisms. The final chapter explores the possible ecological significance of these products. The second edition incorporates new material on the isolation and characterization of the enzymes of secondary metabolism and on the new NMR techniques which have revolutionized the elucidation of biosynthetic pathways. The book is important reading for advanced undergraduates and graduates in chemistry, biochemistry, and botany, as well as researchers in the pharmaceutical industry. |
Contents
INTRODUCTION | 1 |
Saturated fatty acids Unsaturated fatty acids The polyacetylenes | 34 |
ISOPRE | 79 |
Copyright | |
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Common terms and phrases
active alkaloids alkylation amino acids antibiotics aromatic biogenesis biogenetic biological biosynthetic biosynthetic pathway C₁ C₂ units carbon atoms cardenolides CH₂ CH₂OH Chem chemical cholesterol cinnamic acid CO,H CO₂H CO₂H CO₂H CO₂H OH CO₂Me compounds COSCOA coupling cyclization derived from shikimate DMAPP enzyme esters example fatty acids flavonoids fungal H H H H OH H₂N H H₂O higher plants HO₂C hormones incorporated insects interactions intermediate isoprene isoprenoids labelling pattern MeO MeO MeO OMe MeO₂C metabolic pathways methyl groups mode molecules monoterpenes NADPH natural products NH₂ occur Oglucose OH CO₂H OH H OH OH OH organisms oxidative phenols phenylalanine pheromones polyketide precursor probably produced prostaglandins pyrophosphate reactions recently ring S-adenosyl methionine SCOA secondary metabolites sesquiterpenes shikimic acid shown in equation shown in Fig side-chain skeletal types skeletons species squalene steroids structural sub-unit substrate synthesized terpenes tion toxic tracer triterpenes tyrosine utilized vitamin ОН ОН