Nature, Volume 253 |
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Page 181
Table 1 Effects of repeated methadone treatment on methadone and morphine
lethality and activity of liver N-demethylase in mice rendered tolerant by
implantation of a morphine pellet Treatment Methadone LDso + s.e. Morphine
LDso -i- s.e. ...
Table 1 Effects of repeated methadone treatment on methadone and morphine
lethality and activity of liver N-demethylase in mice rendered tolerant by
implantation of a morphine pellet Treatment Methadone LDso + s.e. Morphine
LDso -i- s.e. ...
Page 182
Table 2 Effect of phenobarbital treatment on methadone and morphine lethality
and activity of liver N-demethylase in naive mice Treatment Methadone LD50 +
S.e. Morphine LDso -i- s.e. "TN-demethylase activity (pumol (mg kg”) (mg kg”) ...
Table 2 Effect of phenobarbital treatment on methadone and morphine lethality
and activity of liver N-demethylase in naive mice Treatment Methadone LD50 +
S.e. Morphine LDso -i- s.e. "TN-demethylase activity (pumol (mg kg”) (mg kg”) ...
Page 183
... with methadone or morphine before mating METHADONE ((+)-4, 4-diphenyl-6-
dimethylamino-3-heptanone hydrochloride) ... resulting from heroin withdrawal
led to the introduction of methadone in the chemotherapy of narcotic addiction***.
... with methadone or morphine before mating METHADONE ((+)-4, 4-diphenyl-6-
dimethylamino-3-heptanone hydrochloride) ... resulting from heroin withdrawal
led to the introduction of methadone in the chemotherapy of narcotic addiction***.
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