Chronic Infection, Chlamydia and Coronary Heart DiseaseCoronary heart disease (CHD) remains a major cause of human mortality and morbidity worldwide. Classical risk factors for atherosclerosis fail to account fully for the wide variations in CHD prevalence and/or severity between differing populations. The search for hitherto unrecognised risk factors has recently focused on the potential role of chronic inflammation and common infections. Chronic Infection, Chlamydia and Coronary Heart Disease is the first book to review the wealth of evidence linking various infective agents with CHD, focusing particularly on the proposed pathogenetic role of the main candidate microorganism, Chlamydia pneumoniae. Written by two leading investigators in the field, the book provides a concise, clearly written and up-to-date account of the diverse lines of evidence - seroepidemiological, pathological, animal and in vitro data and clinical antibiotic trials. The possibility of an infective basis to atherosclerosis and CHD has already attracted much scientific interest. Chronic Infection, Chlamydia and Coronary Heart Disease highlights the key published works on the topic, and concludes with information on existing, ongoing, and future lines of enquiry. |
Other editions - View all
Chronic Infection, Chlamydia and Coronary Heart Disease S. Gupta,A.J. Camm No preview available - 2014 |
Chronic Infection, Chlamydia and Coronary Heart Disease S. Gupta,A.J. Camm No preview available - 1999 |
Common terms and phrases
angiographically anti-C antibiotic antigen aorta aortic association atherogenesis atherogenic atheromatous atherosclerosis atherosclerotic disease atherosclerotic lesions atherosclerotic plaques azithromycin blood C-reactive protein cardiac cardiovascular disease cardiovascular events cardiovascular risk factors carotid case-control study Chlamydia pneumoniae Chlamydia pneumoniae infection chlamydial infections cholesterol chronic infection Circulation 1998 Clin clinical CMV infection Coll Cardiol controls coronary artery disease coronary heart disease coronary stenosis cytokines cytomegalovirus dental detected diabetes mellitus elevated endothelial cells endothelium epidemiological evidence fibrinogen Grayston JT Helicobacter pylori human immune increased infections and coronary inflammation investigators ISBN ischaemic Lancet leucocyte lipid macrophages markers mechanisms Mendall Microbiol microimmunofluorescence monocytes myocardial infarction neopterin odds ratio organism pathogenesis of atherosclerosis Pathol patients plasma pneumoniae antibody titres population potential prevalence prospective study respiratory infections restenosis role Saikku serological seropositivity serum smoking smooth muscle cells suggested therapy tissue factor trachomatis TWAR unstable angina vascular virus vitro