Pediatric Bone: Biology & DiseasesPediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children Key Features * Deals exclusively with bone development and diseases of children and each chapter written by an * Fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values * Covers both the physiology of bone and mineral homeostasis in children and diseases in one book * Includes a CD-ROM of images |
Contents
Collagen | 6 |
Collagen | 14 |
Perlecan | 20 |
Bone Acidic Glycoprotein75 | 26 |
Ontogeny | 77 |
Molecular Regulation of Bone Formation | 96 |
References | 104 |
Endochondral and Intramembranous Bone | 119 |
Reliability | 333 |
Biochemical Markers of Bone | 339 |
Puberty | 346 |
Clinical and Research Value of Biochemical Markers | 352 |
The Role of the Mechanostat in the Pathogenesis | 403 |
Approach to Prevention and Intervention | 426 |
Introduction 375 | 473 |
Summary | 480 |
Fibroblast Growth Factors | 122 |
References | 130 |
Parathyroids and Secretion and Metabolism | 139 |
Assay of PTH | 147 |
References | 160 |
Phosphate Homeostasis Regulatory | 173 |
Pathophysiological Aspects | 181 |
References | 187 |
Vitamin D Biology | 193 |
Role of Vitamin D in Calcium Homeostasis | 201 |
Summary and Perspectives | 208 |
Other Factors Controlling Bone Growth | 217 |
Parathyroid HormoneRelated Protein | 223 |
Introduction | 249 |
Lactation | 255 |
Summary | 264 |
Fetal Mineral Homeostasis | 271 |
Placental Calcium Transport | 280 |
Placental Transport of Magnesium | 288 |
References | 296 |
Noninvasive Techniques for Bone Mass | 303 |
Data Interpretation | 316 |
Bone Age | 325 |
Introduction | 485 |
Hypercalcemic Diseases | 496 |
References | 502 |
Fibrous Dysplasia | 509 |
Molecular Genetics | 516 |
Pathogenesis | 526 |
References | 533 |
Introduction 603 | 541 |
References | 560 |
Metabolic Bone Disease of Prematurity | 567 |
Suggested Guidelines for the Prevention of Metabolic | 578 |
Introduction | 633 |
Renal Magnesium Wasting | 640 |
Conclusion | 647 |
Clinical Hypophosphatasia | 661 |
References | 672 |
Introduction 583 | 679 |
Clinical Manifestations | 685 |
Treatment | 691 |
Bone Tumors in Children | 703 |
| 745 | |
Other editions - View all
Pediatric Bone: Biology and Diseases Francis H. Glorieux,John M. Pettifor,Harald Jüppner Limited preview - 2011 |
Common terms and phrases
1,25-dihydroxyvitamin abnormalities activity adolescents adult amino acid amylin autosomal Biochem Biol bisphosphonate bone density bone formation bone mass bone mineral density bone resorption Ca2+ calcitonin calcium calcium transfer cartilage cells Chem chondrocytes chromosome Clin clinical cortical cotransporter defect differentiation disease disorders domain dysplasia effect encoding Endocrinol Endocrinology exon expression extracellular fetal fetuses fibrils fractures function gene Genet growth factor growth plate homeostasis human hypercalcemia hyperparathyroidism increased inhibits interactions kidney lactation levels limb markers maternal matrix maturation mesenchymal Metab metabolism mice molecular molecules mouse mRNA mutations normal osteo osteoblast osteocalcin osteocytes osteogenesis imperfecta osteopontin osteoporosis parathyroid hormone patients Pediatr peptide phenotype phosphate placenta placental calcium pregnancy procollagen proliferation protein proteoglycan PTHrP puberty receptor regulation renal residues role sequence serum signaling skeletal skeleton studies syndrome therapy tion tissue trabecular transcription factor type I collagen vertebral vitamin vitro vivo