Cancer, Principles and Practice of Oncology, Volume 1

abnormalities activation addition agents antigen apoptosis appears associated binding Biol breast cancer carcinoma cause cell cycle cell death cellular changes chemotherapy chromosome clinical common complex cyclin cytokines cytoplasmic cytotoxic damage death disease domain dose drug effects et al example exposure expression factor FIGURE function gene genetic growth growth factor human identified immune Immunol important increased individual induced infection inhibition initial interaction involved kinase known lead leukemia levels ligands lung lymphocytes lymphoma major malignant mechanisms mediated Medicine membrane mice molecular molecules mutations Nature normal occur oncogene Oncology pathway patients peptide phase potential present progression proliferation promote protein radiation receptor region regulation response result risk role Science selection sequence signaling specific stimulation structure studies surface T-cell therapy tion tissue transcription treatment tumor cells virus