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The loxP sites are shown as triangles, Rhcg exons as black boxes, B, Bam H.I
sites used in DNA blot analysis with the exon 11 probe (P). p3S, p8]uescript. b—e
, Demonstration of correct Rhcg targeting, b, Blot analysis of DNA ...
NATUREVol 456|20 November 2008 T'". a b as 74]Rhcgi/ - Rhog--  Rhog+/- =
Rhcg-/Acid load 520 Acid load 7.3 & # 31s § 7.2 + + T m * g 10 É 7.1 D 5 7.0 O 0
2 6 O 2 6 C Days d Days 501DRhcgt. LRhcg-- 8.0, CRhcgi/ - Rhog-- Acid load *xr
b a O Na /20 mMNH,C 6.65 2— Rhcg" s - –/- £ Rhcg o 6.55 E -- T. T I O. 9. 6.45 *
Q) O. I g 6.35 0 50 100 150 Time (s) Figure 3 | Reduced NHs permeability of
microperfused collecting ducts segments from Rhcg' acid-challenged mice.
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activity alleles analysis APOBEC3G applications associated autophagy behaviour Biol biology brain calpain cancer candidate cell biology Center changes channel chromatin climate complex CRTC2 cycle dark matter detected diatoms disease DNA methylation domain dynamics effect electron emission energy experiments expression function genes genetic genome sequence genotype Holliday junction human adult GSCs imaging Institute interactions larvae mammoth melanotrope Methods methylation mice molecular mutations nanowires Nature Naturejobs neurons Neurosci nuclear º º observed optical paddle motifs Paneth cells phototaxis Phys position PPAR-Y predation predicted protein quantum quantum dot receptor region response Rhcg role sample Science scientific scientists signal simulations SNPs specific spin stem cells structure studies Supplementary Fig Supplementary Information Supplementary Table target temperature tion toxin transcription tumour University variants wild-type yeast