Secondary MetabolismThis book is concerned with the biosynthesis, biological activity, and ecological significance of secondary metabolites (natural products).These include alcaloids such as morphine, steroids like cholesterol, and antibiotics like the penicillins. The author considers each of the major classes of secondary metabolites according to the basic 'building blocks' from which they are derived and highlights the pharmacological and toxicological properties of compounds found in insects, plants, and microorganisms. The final chapter explores the possible ecological significance of these products. The second edition incorporates new material on the isolation and characterization of the enzymes of secondary metabolism and on the new NMR techniques which have revolutionized the elucidation of biosynthetic pathways. The book is important reading for advanced undergraduates and graduates in chemistry, biochemistry, and botany, as well as researchers in the pharmaceutical industry. |
Contents
METABOLITES DERIVED FROM SHIKIMIC ACID | 173 |
THE SECONDARY METABOLISM OF AMINO ACIDS | 191 |
METABOLITES OF MIXED BIOSYNTHETIC ORIGIN | 261 |
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Common terms and phrases
acetyl-SCOA active alkaloids alkylation amino acids antibiotics aromatic biogenesis biogenetic biological biosynthesis biosynthetic pathway C₁ carbon atoms cardenolides CH₂ CH₂OH Chem chemical chemistry cholesterol cinnamic acid CO,H CO₂ CO₂H CO₂H CO₂H CO₂H OH CO₂Me compounds COSCOA coupling cyclization deuterium DMAPP enzyme esters example fatty acids flavonoids fungal glucose H H H H OH H₂N H H₂O higher plants HO₂C hydrogen hydroxylation incorporated insects interactions intermediate isolated isoprene isoprenoids isotopically labelling pattern MeO MeO MeO OH MeO₂C metabolic pathways methyl groups molecule monoterpenes NADPH Natural Product Reports NH₂ occur OH CO₂H OH H OH OH OH organisms oxidative pathway shown phenols phenylalanine pheromones polyketide precursor probably produced prostaglandins pyrophosphate reactions reduction ring S-adenosyl methionine SCOA secondary metabolites SEnz sesquiterpenes shikimic acid shown in eqn shown in Fig side-chain species steroid structural sub-unit substrate synthesized terpenes toxic tracer tryptophan tyrosine utilized vitamin ОН