Handbook of Radiopharmaceuticals: Radiochemistry and ApplicationsMichael J. Welch, Carol S. Redvanly A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States |
Contents
Accelerators Available for Isotope Production | 71 |
Reactor Production of Radionuclides | 87 |
Chemistry of Nitrogen13 and Oxygen15 | 119 |
Aspects on the Synthesis of 11CLabelled Compounds | 141 |
Chemistry of Fluorine18 Radiopharmaceuticals | 195 |
Production and Application of Synthetic Precursors Labeled with | 229 |
Automation for the Synthesis and Application of PET Radiopharmaceuticals | 283 |
Design and Synthesis of 2Deoxy218FFluoroDGlucose 18FDG | 307 |
Strategies for Quantifying PET Imaging Data from | 501 |
Radiopharmaceuticals for Studying the Heart | 529 |
PET Imaging Studies in Drug Abuse Research | 557 |
Research and Clinical Application of Neuroreceptor Imaging | 581 |
Dynamic Neurotransmitter Interactions Measured with PET | 603 |
Tumor Imaging | 629 |
Radiolabeled Peptides for Tumor Imaging | 643 |
Radiolabeled Antibodies for Tumor Imaging and Therapy | 685 |
Technetium Radiopharmaceuticals | 323 |
Chemistry of Gallium and Indium Radiopharmaceuticals | 363 |
Chemistry of Copper Radionuclides and Radiopharmaceutical Products | 401 |
Chemistry Applied to Iodine Radionuclides | 423 |
Radiobromine for Imaging and Therapy | 441 |
Development of Radiolabeled Probes to Monitor Gene Therapy | 467 |
Mechanism of Target Specific Uptake Using Examples | 487 |
Receptor Imaging of Tumors NonPeptide | 715 |
Pulmonary Function Imaging with PET Radiopharmaceuticals | 751 |
Considerations in the Selection of Radionuclides for Cancer Therapy | 767 |
| 787 | |
Radiopharmaceuticals for the Study of Liver and Renal Function | 795 |
| 823 | |
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Common terms and phrases
1F]fluoride affinity amino acids analogues antibody Appl application aromatic automated biodistribution Biol blood flow brain bromide C-labelled C]carbon C]methyl cancer carbon cells chelate Chem chemical chemistry clinical cocaine complex compounds Crouzel cyclotron decay dopamine transporter dose drug electrophilic energy enzyme estrogen evaluation fluorine fluorine-18 fluorine-18 labeled Fowler function gene half-life Halldin high specific activity human imaging agents injection iodide iodine irradiation Isot Isotopes Katzenellenbogen Kilbourn kinetic Labelled Compd Långström ligands liver metabolism method methyl molecule myocardial neutron nitrogen-13 no-carrier-added Nucl Nuclear Medicine nuclear reactions nucleophilic octreotide oxide particle patients peptide PET imaging PET studies plasma positron emission tomography potential precursor prepared production protein proton radioactivity radiochemical yield radioiodine radioisotopes radiolabeled radioligand radionuclide Radiopharm radiopharmaceuticals radiotracer rats reagents receptor binding Schlyer serotonin somatostatin synthesis target Targetry technetium therapy tissue tracer tumor uptake vitro vivo Volkow Welch MJ Wolf AP
Popular passages
Page 681 - Pierschbacher MD and Ruoslahti E (1984). Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.