Nature, Volume 454Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 226
... IRF4 inhibition is toxic to myeloma cell lines , regardless of transforming oncogenic mechanism . Gene express- ion profiling and genome - wide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes ...
... IRF4 inhibition is toxic to myeloma cell lines , regardless of transforming oncogenic mechanism . Gene express- ion profiling and genome - wide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes ...
Page 227
... IRF4 locus . To understand the molecular basis for this dependency , we iden- tified downstream targets of IRF4 by profiling gene expression changes in myeloma lines after induction of IRF4 shRNAs ( Supplementary Fig . 3 ) . A total of ...
... IRF4 locus . To understand the molecular basis for this dependency , we iden- tified downstream targets of IRF4 by profiling gene expression changes in myeloma lines after induction of IRF4 shRNAs ( Supplementary Fig . 3 ) . A total of ...
Page 228
... IRF4 IRF4 IRF4 MYC mRNA : B2M IRF4 MYC MYC Relative mRNA expression 3.5 3.0 ChIP signal ( arbitrary units ) 0.16 0.14 0.12 0.10 0.08 0.06 0.04 0.02 ctrl IRF4 + ChIP signal ( arbitrary units ) σ 87654321 · IRF4 ctrl IRF4 OCI- KMS12 OCI ...
... IRF4 IRF4 IRF4 MYC mRNA : B2M IRF4 MYC MYC Relative mRNA expression 3.5 3.0 ChIP signal ( arbitrary units ) 0.16 0.14 0.12 0.10 0.08 0.06 0.04 0.02 ctrl IRF4 + ChIP signal ( arbitrary units ) σ 87654321 · IRF4 ctrl IRF4 OCI- KMS12 OCI ...
Contents
More CO2 means more | 46 |
ARTICLES | 49 |
SMAD proteins control DROSHAmediated microRNA maturation | 56 |
Copyright | |
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